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IMS1 2-isopropylmalate synthase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843742, updated on 18-Sep-2024

Summary

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Official Symbol
IMS1
Official Full Name
2-isopropylmalate synthase 1
Primary source
TAIR:AT1G74040
Locus tag
AT1G74040
See related
Araport:AT1G74040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
2-isopropylmalate synthase 1; 2-ISOPROPYLMALATE SYNTHASE 1; F2P9.9; F2P9_9; IPMS2; ISOPROPYLMALATE SYNTHASE 2; MAML-3; SOPROPYLMALATE SYNTHASE 2
Summary
Encodes an active Arabidopsis isopropylmalate synthase IPMS2. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS2 can be compensated by a second isopropylmalate synthase gene IPMS1 (At1g18500).
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Genomic context

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See IMS1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (27842109..27845782)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene strictosidine synthase 2 Neighboring gene uncharacterized protein Neighboring gene enolase 1 Neighboring gene tetraspanin-17 protein Neighboring gene Ribosomal protein L6 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis. de Kraker JW, et al. Plant Cell, 2011 Jan. PMID 21205930, Free PMC Article
  2. Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine. de Kraker JW, et al. Plant Physiol, 2007 Feb. PMID 17189332, Free PMC Article
  3. Isolation and expression analysis of the isopropylmalate synthase gene family of Arabidopsis thaliana. Junk DJ, et al. J Exp Bot, 2002 Dec. PMID 12432038
  4. Glucosinolate and amino acid biosynthesis in Arabidopsis. Field B, et al. Plant Physiol, 2004 Jun. PMID 15155874, Free PMC Article
  5. A Regulatory Hierarchy of the Arabidopsis Branched-Chain Amino Acid Metabolic Network. Xing A, et al. Plant Cell, 2017 Jun. PMID 28522547, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the C-terminal domain of IPMS increases MAM activity.
    Title: From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis.
  2. Two isopropylmalate synthase genes from A. thaliana are described.
    Title: Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001334624.1
NM_001334625.1
NM_106063.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 2-isopropylmalate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-isopropylmalate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-isopropylmalate synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables 2-isopropylmalate synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-leucine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-leucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-leucine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 

General protein information

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Preferred Names
2-isopropylmalate synthase 1
NP_177544.1
  • 2-isopropylmalate synthase 1 (IMS1); FUNCTIONS IN: 2-isopropylmalate synthase activity; INVOLVED IN: leucine biosynthetic process; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Alpha-isopropylmalate/homocitrate synthase, conserved site (InterPro:IPR002034), 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain (InterPro:IPR013709), Pyruvate carboxyltransferase (InterPro:IPR000891), Bacterial 2-isopropylmalate synthase (InterPro:IPR005671); BEST Arabidopsis thaliana protein match is: methylthioalkylmalate synthase-like 4 (TAIR:AT1G18500.1); Has 16891 Blast hits to 16883 proteins in 2449 species: Archae - 499; Bacteria - 8886; Metazoa - 193; Fungi - 474; Plants - 279; Viruses - 0; Other Eukaryotes - 6560 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    27842109..27845782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106063.3 → NP_177544.1  2-isopropylmalate synthase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_177544.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GWX8, Q9C550
    UniProtKB/TrEMBL
    A0A178WEK1, A0A5S9WU76
    Conserved Domains (3) summary
    cd07940
    Location:89 → 368
    DRE_TIM_IPMS; 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain
    smart00917
    Location:466 → 609
    LeuA_dimer; LeuA allosteric (dimerisation) domain
    PLN02321
    Location:5 → 631
    PLN02321; 2-isopropylmalate synthase

  2. NM_001334624.1 → NP_001322763.1  2-isopropylmalate synthase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WEK1, A0A1P8AUZ8, A0A5S9WU76

  3. NM_001334625.1 → NP_001322762.1  2-isopropylmalate synthase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AV04
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C550.1

Gene LinkOut

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