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HSP101 heat shock protein 101 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843771, updated on 18-Sep-2024

Summary

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Official Symbol
HSP101
Official Full Name
heat shock protein 101
Primary source
TAIR:AT1G74310
Locus tag
AT1G74310
See related
Araport:AT1G74310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATHSP101; F1O17.2; F1O17_2; heat shock protein 101; HEAT SHOCK PROTEIN ATHSP101; HOT1
Summary
Encodes ClpB1, which belongs to the Casein lytic proteinase/heat shock protein 100 (Clp/Hsp100) family. Involved in refolding of proteins which form aggregates under heat stress. Also known as AtHsp101. AtHsp101 is a cytosolic heat shock protein required for acclimation to high temperature.
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Genomic context

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See HSP101 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Sequence:
Chromosome: 1; NC_003070.9 (27936508..27940369, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein Neighboring gene Protein kinase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis plants overexpressing additional copies of heat shock protein Hsp101 showed high heat tolerance and endo-gene silencing. Babbar R, et al. Plant Sci, 2023 May. PMID 36796649
  2. An Arabidopsis heat shock protein complements a thermotolerance defect in yeast. Schirmer EC, et al. Plant Cell, 1994 Dec. PMID 7866032, Free PMC Article
  3. Genetic analysis reveals domain interactions of Arabidopsis Hsp100/ClpB and cooperation with the small heat shock protein chaperone system. Lee U, et al. Plant Cell, 2005 Feb. PMID 15659638, Free PMC Article
  4. The xenobiotic beta-aminobutyric acid enhances Arabidopsis thermotolerance. Zimmerli L, et al. Plant J, 2008 Jan. PMID 18047473
  5. Heat shock protein 101 effects in A. thaliana: genetic variation, fitness and pleiotropy in controlled temperature conditions. Tonsor SJ, et al. Mol Ecol, 2008 Mar. PMID 18321256, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis plants overexpressing additional copies of heat shock protein Hsp101 showed high heat tolerance and endo-gene silencing.
    Title: Arabidopsis plants overexpressing additional copies of heat shock protein Hsp101 showed high heat tolerance and endo-gene silencing.
  2. Heat shock protein 101 (HSP101) promotes flowering under nonstress conditions.
    Title: Heat shock protein 101 (HSP101) promotes flowering under nonstress conditions.
  3. after heat shock, HSP101 is required for the efficient release of RP mRNAs from stress granules resulting in a rapid restoration of the translation machinery by producing new ribosomal proteins.
    Title: Heat Shock Protein HSP101 Affects the Release of Ribosomal Protein mRNAs for Recovery after Heat Shock.
  4. Data show that both class I and II small heat shock proteins (sHSPs) were present in cytosolic foci, some of which colocalized with HSP101 and with eEF1Bgamma and eEF1Bbeta.
    Title: Class I and II Small Heat Shock Proteins Together with HSP101 Protect Protein Translation Factors during Heat Stress.
  5. a positive feedback loop between HSP101 and HSA32 at the protein level is a novel mechanism for prolonging the memory of heat acclimation.
    Title: Interplay between heat shock proteins HSP101 and HSA32 prolongs heat acclimation memory posttranscriptionally in Arabidopsis.
  6. This study shows that Hsp101 expression is evolvable in natural populations.Hsp101 is primarily an emergency high-temperature tolerance mechanism, since expression levels are lower in low-latitude populations from warmer climates.
    Title: Heat shock protein 101 effects in A. thaliana: genetic variation, fitness and pleiotropy in controlled temperature conditions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001334640.1
NM_106091.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
acts_upstream_of_or_within positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein unfolding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to heat IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to high light intensity IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
heat shock protein 101
NP_565083.1
  • heat shock protein 101 (HSP101); FUNCTIONS IN: protein binding, ATPase activity, ATP binding; INVOLVED IN: response to high light intensity, response to hydrogen peroxide, response to heat, protein unfolding; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Clp ATPase, C-terminal (InterPro:IPR019489), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-2 (InterPro:IPR013093), ATPase, AAA-type, core (InterPro:IPR003959), Chaperonin clpA/B (InterPro:IPR001270), Chaperonin ClpA/B, conserved site (InterPro:IPR018368), Clp, N-terminal (InterPro:IPR004176); BEST Arabidopsis thaliana protein match is: casein lytic proteinase B2 (TAIR:AT4G14670.1); Has 27671 Blast hits to 24472 proteins in 3146 species: Archae - 360; Bacteria - 17866; Metazoa - 1124; Fungi - 430; Plants - 707; Viruses - 13; Other Eukaryotes - 7171 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    27936508..27940369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106091.4 → NP_565083.1  heat shock protein 101 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565083.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42730, Q8W4F2, Q9LE57
    UniProtKB/TrEMBL
    A0A5S9WUB5, A0A654EZK7
    Conserved Domains (1) summary
    TIGR03346
    Location:6 → 856
    chaperone_ClpB; ATP-dependent chaperone ClpB

  2. NM_001334640.1 → NP_001320516.1  heat shock protein 101 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W7U9, A0A1P8AN20, A0A384K8A9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42730.2

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