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BZR1 Brassinosteroid signaling positive regulator (BZR1) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843845, updated on 18-Sep-2024

Summary

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Official Symbol
BZR1
Official Full Name
Brassinosteroid signaling positive regulator (BZR1) family protein
Primary source
TAIR:AT1G75080
Locus tag
AT1G75080
See related
Araport:AT1G75080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
BRASSINAZOLE-RESISTANT 1; F9E10.7; F9E10_7
Summary
Encodes a positive regulator of the brassinosteroid (BR) signalling pathway that mediates both downstream BR responses and negative feedback regulation of BR biosynthesis. There is evidence for phosphorylation-dependent nucleocytoplasmic shuttling of BZR1. GSK3-like kinases (including BIN2), 14-3-3 proteins, and the phosphatase BSU1 seem to participate in this process. Phosphorylation also appears to affect BZR1's transcriptional activities.
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Genomic context

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See BZR1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (28185504..28188075)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene histone deacetylase complex subunit Neighboring gene tRNA-Asp Neighboring gene ncRNA Neighboring gene DNA glycosylase superfamily protein Neighboring gene ncRNA Neighboring gene J-domain protein required for chloroplast accumulation response 1 Neighboring gene Nucleotide-diphospho-sugar transferase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Highlighting the potential utility of MBP crystallization chaperone for Arabidopsis BIL1/BZR1 transcription factor-DNA complex. Nosaki S, et al. Sci Rep, 2021 Feb 16. PMID 33594119, Free PMC Article
  2. The brassinosteroid-regulated transcription factors BZR1/BES1 function as a coordinator in multisignal-regulated plant growth. Li QF, et al. Biochim Biophys Acta Gene Regul Mech, 2018 Jun. PMID 29673687
  3. Light involved regulation of BZR1 stability and phosphorylation status to coordinate plant growth in Arabidopsis. Li QF, et al. Biosci Rep, 2017 Apr 30. PMID 28396515, Free PMC Article
  4. Brassinazole resistant 1 (BZR1)-dependent brassinosteroid signalling pathway leads to ectopic activation of quiescent cell division and suppresses columella stem cell differentiation. Lee HS, et al. J Exp Bot, 2015 Aug. PMID 26136267, Free PMC Article
  5. Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT1 in Arabidopsis thaliana. Wang R, et al. Proc Natl Acad Sci U S A, 2021 Aug 17. PMID 34385302, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brassinosteroid regulates stomatal development in etiolated Arabidopsis cotyledons via transcription factors BZR1 and BES1.
    Title: Brassinosteroid regulates stomatal development in etiolated Arabidopsis cotyledons via transcription factors BZR1 and BES1.
  2. Comparative analysis of BZR1/BES1 family transcription factors in Arabidopsis.
    Title: Comparative analysis of BZR1/BES1 family transcription factors in Arabidopsis.
  3. Vacuolar H[+]-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling in Arabidopsis.
    Title: Vacuolar H(+)-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling in Arabidopsis.
  4. The BZR1-EDS1 module regulates plant growth-defense coordination.
    Title: The BZR1-EDS1 module regulates plant growth-defense coordination.
  5. Highlighting the potential utility of MBP crystallization chaperone for Arabidopsis BIL1/BZR1 transcription factor-DNA complex.
    Title: Highlighting the potential utility of MBP crystallization chaperone for Arabidopsis BIL1/BZR1 transcription factor-DNA complex.
  6. Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT1 in Arabidopsis thaliana.
    Title: Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT1 in Arabidopsis thaliana.
  7. BZR1 Physically Interacts with SPL9 to Regulate the Vegetative Phase Change and Cell Elongation in Arabidopsis.
    Title: BZR1 Physically Interacts with SPL9 to Regulate the Vegetative Phase Change and Cell Elongation in Arabidopsis.
  8. Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1.
    Title: Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1.
  9. SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth.
    Title: SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth.
  10. BES1/BZR1 Homolog 3 cooperates with E3 ligase AtRZF1 to regulate osmotic stress and brassinosteroid responses in Arabidopsis.
    Title: BES1/BZR1 Homolog 3 cooperates with E3 ligase AtRZF1 to regulate osmotic stress and brassinosteroid responses in Arabidopsis.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_106164.3
NM_202416.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brassinosteroid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within plant ovule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within seed development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Brassinosteroid signaling positive regulator (BZR1) family protein
NP_565099.1
  • BRASSINAZOLE-RESISTANT 1 (BZR1); CONTAINS InterPro DOMAIN/s: BZR1, transcriptional repressor (InterPro:IPR008540); BEST Arabidopsis thaliana protein match is: Brassinosteroid signalling positive regulator (BZR1) family protein (TAIR:AT1G19350.3); Has 2999 Blast hits to 628 proteins in 98 species: Archae - 0; Bacteria - 16; Metazoa - 199; Fungi - 166; Plants - 281; Viruses - 0; Other Eukaryotes - 2337 (source: NCBI BLink).
NP_974145.1
  • BRASSINAZOLE-RESISTANT 1 (BZR1); CONTAINS InterPro DOMAIN/s: BZR1, transcriptional repressor (InterPro:IPR008540); BEST Arabidopsis thaliana protein match is: Brassinosteroid signalling positive regulator (BZR1) family protein (TAIR:AT1G19350.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    28185504..28188075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_202416.1 → NP_974145.1  Brassinosteroid signaling positive regulator (BZR1) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974145.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8S307, Q8VZD2, Q9C9Q2
    UniProtKB/TrEMBL
    A0A178WJU2, A0A5S9WUH8
    Conserved Domains (1) summary
    pfam05687
    Location:22 → 129
    BES1_N; BES1/BZR1 plant transcription factor, N-terminal

  2. NM_106164.3 → NP_565099.1  Brassinosteroid signaling positive regulator (BZR1) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565099.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8S307, Q8VZD2, Q9C9Q2
    UniProtKB/TrEMBL
    A0A178WJU2, A0A5S9WUH8
    Conserved Domains (1) summary
    pfam05687
    Location:22 → 129
    BES1_N; BES1/BZR1 plant transcription factor, N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8S307.1

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