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CML38 calmodulin-like 38 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843998, updated on 18-Sep-2024

Summary

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Official Symbol
CML38
Official Full Name
calmodulin-like 38
Primary source
TAIR:AT1G76650
Locus tag
AT1G76650
See related
Araport:AT1G76650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
calmodulin-like 38; F28O16.2; F28O16_2
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Genomic context

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See CML38 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
2
Sequence:
Chromosome: 1; NC_003070.9 (28766750..28768138, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Calcium-binding EF-hand family protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene Nucleotide-sugar transporter family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis CALMODULIN-LIKE 38 Regulates Hypoxia-Induced Autophagy of SUPPRESSOR OF GENE SILENCING 3 Bodies. Field S, et al. Front Plant Sci, 2021. PMID 34567037, Free PMC Article
  2. Arabidopsis CML38, a Calcium Sensor That Localizes to Ribonucleoprotein Complexes under Hypoxia Stress. Lokdarshi A, et al. Plant Physiol, 2016 Feb. PMID 26634999, Free PMC Article
  3. CALMODULIN-LIKE-38 and PEP1 RECEPTOR 2 integrate nitrate and brassinosteroid signals to regulate root growth. Song X, et al. Plant Physiol, 2021 Nov 3. PMID 34618046, Free PMC Article
  4. Arabidopsis thaliana rapid alkalinization factor 1-mediated root growth inhibition is dependent on calmodulin-like protein 38. Campos WF, et al. J Biol Chem, 2018 Feb 9. PMID 29282286, Free PMC Article
  5. Developmental and stimulus-induced expression patterns of Arabidopsis calmodulin-like genes CML37, CML38 and CML39. Vanderbeld B, et al. Plant Mol Biol, 2007 Aug. PMID 17579812

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CALMODULIN-LIKE-38 and PEP1 RECEPTOR 2 integrate nitrate and brassinosteroid signals to regulate root growth.
    Title: CALMODULIN-LIKE-38 and PEP1 RECEPTOR 2 integrate nitrate and brassinosteroid signals to regulate root growth.
  2. a new component of the AtRALF1 response pathway is a calmodulin-like protein that binds AtRALF1, is essential for root growth inhibition, and has no role in AtRALF1 alkalinization.
    Title: Arabidopsis thaliana rapid alkalinization factor 1-mediated root growth inhibition is dependent on calmodulin-like protein 38.
  3. CML38 is a core hypoxia response calcium sensor protein.
    Title: Arabidopsis CML38, a Calcium Sensor That Localizes to Ribonucleoprotein Complexes under Hypoxia Stress.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001084365.1
NM_001198484.1
NM_106315.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
involved_in nitrate assimilation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of brassinosteroid mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calmodulin-like 38
NP_001077834.1
  • calmodulin-like 38 (CML38); FUNCTIONS IN: calcium ion binding; INVOLVED IN: response to wounding; LOCATED IN: plasma membrane; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: Calcium-binding EF-hand family protein (TAIR:AT1G76640.1); Has 9270 Blast hits to 8846 proteins in 1061 species: Archae - 0; Bacteria - 21; Metazoa - 3654; Fungi - 1209; Plants - 2975; Viruses - 0; Other Eukaryotes - 1411 (source: NCBI BLink).
NP_001185413.1
  • calmodulin-like 38 (CML38); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: Calcium-binding EF-hand family protein (TAIR:AT1G76640.1).
NP_177791.1
  • calmodulin-like 38 (CML38); FUNCTIONS IN: calcium ion binding; INVOLVED IN: response to wounding; LOCATED IN: plasma membrane; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992); BEST Arabidopsis thaliana protein match is: Calcium-binding EF-hand family protein (TAIR:AT1G76640.1); Has 14301 Blast hits to 11244 proteins in 1181 species: Archae - 0; Bacteria - 48; Metazoa - 5820; Fungi - 2427; Plants - 3932; Viruses - 0; Other Eukaryotes - 2074 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    28766750..28768138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106315.3 → NP_177791.1  calmodulin-like 38 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_177791.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MQS8, Q8LBV6, Q9SRE6
    UniProtKB/TrEMBL
    A0A178WMC5, A0A5S9WUX2
    Conserved Domains (1) summary
    PTZ00183
    Location:38 → 177
    PTZ00183; centrin; Provisional

  2. NM_001084365.1 → NP_001077834.1  calmodulin-like 38 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077834.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9WUX2
    Conserved Domains (2) summary
    PTZ00184
    Location:38 → 166
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:43 → 95
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. NM_001198484.1 → NP_001185413.1  calmodulin-like 38 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185413.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MQS8, Q8LBV6, Q9SRE6
    UniProtKB/TrEMBL
    A0A178WMC5, A0A5S9WUX2
    Conserved Domains (1) summary
    PTZ00183
    Location:38 → 177
    PTZ00183; centrin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SRE6.1

Gene LinkOut

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