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LACS9 long chain acyl-CoA synthetase 9 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 844094, updated on 18-Sep-2024

Summary

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Official Symbol
LACS9
Official Full Name
long chain acyl-CoA synthetase 9
Primary source
TAIR:AT1G77590
Locus tag
AT1G77590
See related
Araport:AT1G77590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
long chain acyl-CoA synthetase 9; T5M16.18; T5M16_18
Summary
Encodes major plastidic long chain acyl-CoA synthetase with a slight substrate preference of oleic acid over any of the other fatty acids.
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Genomic context

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See LACS9 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (29148160..29152395, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Winged helix-turn-helix transcription repressor DNA-binding protein Neighboring gene filament-like protein (DUF869) Neighboring gene ARM repeat superfamily protein Neighboring gene EamA-like transporter family protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fatty acid export from the chloroplast. Molecular characterization of a major plastidial acyl-coenzyme A synthetase from Arabidopsis. Schnurr JA, et al. Plant Physiol, 2002 Aug. PMID 12177483, Free PMC Article
  2. Two activities of long-chain acyl-coenzyme A synthetase are involved in lipid trafficking between the endoplasmic reticulum and the plastid in Arabidopsis. Jessen D, et al. Plant Physiol, 2015 Feb. PMID 25540329, Free PMC Article
  3. Insertional mutant analysis reveals that long-chain acyl-CoA synthetase 1 (LACS1), but not LACS8, functionally overlaps with LACS9 in Arabidopsis seed oil biosynthesis. Zhao L, et al. Plant J, 2010 Dec. PMID 21143684
  4. Arabidopsis contains nine long-chain acyl-coenzyme a synthetase genes that participate in fatty acid and glycerolipid metabolism. Shockey JM, et al. Plant Physiol, 2002 Aug. PMID 12177484, Free PMC Article
  5. Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana. Ferro M, et al. Mol Cell Proteomics, 2003 May. PMID 12766230

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The analyses of mutant lines revealed strongly overlapping functions of LACS4 and LACS9 in lipid trafficking from the endoplasmic reticulum to the plastid.
    Title: Two activities of long-chain acyl-coenzyme A synthetase are involved in lipid trafficking between the endoplasmic reticulum and the plastid in Arabidopsis.
  2. LACS1 is localized in the ER and functionally overlaps with LACS9 to supply acyl-CoAs for TAG biosynthesis.
    Title: Insertional mutant analysis reveals that long-chain acyl-CoA synthetase 1 (LACS1), but not LACS8, functionally overlaps with LACS9 in Arabidopsis seed oil biosynthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001334788.1
NM_106407.7

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in plastid HDA PubMed 

General protein information

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Preferred Names
long chain acyl-CoA synthetase 9
NP_177882.1
  • long chain acyl-CoA synthetase 9 (LACS9); FUNCTIONS IN: long-chain fatty acid-CoA ligase activity; INVOLVED IN: fatty acid metabolic process, fatty acid biosynthetic process; LOCATED IN: chloroplast, membrane, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT2G04350.2); Has 68698 Blast hits to 57242 proteins in 3549 species: Archae - 1129; Bacteria - 47028; Metazoa - 2860; Fungi - 3365; Plants - 2152; Viruses - 2; Other Eukaryotes - 12162 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    29148160..29152395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106407.7 → NP_177882.1  long chain acyl-CoA synthetase 9 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_177882.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WLQ0, Q84WQ8, Q9CAP8
    UniProtKB/TrEMBL
    A0A178W2C2, A0A7G2E866
    Conserved Domains (1) summary
    PLN02387
    Location:1 → 691
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  2. NM_001334788.1 → NP_001321320.1  long chain acyl-CoA synthetase 9 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AQK5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CAP8.1

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