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MC5 metacaspase 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 844271, updated on 18-Sep-2024

Summary

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Official Symbol
MC5
Official Full Name
metacaspase 5
Primary source
TAIR:AT1G79330
Locus tag
AT1G79330
See related
Araport:AT1G79330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AMC6; ATMC5; ATMCP2b; ATMCP2B; MCP2b; metacaspase 2b; metacaspase 5; YUP8H12R.5; YUP8H12R_5
Summary
Metacaspase AtMCPb2/AMC6. Caspase family protein. Arginine/lysine-specific cysteine protease activity. Induces apoptosis in yeast. Contains Pfam domain, PF00656: ICE-like protease (caspase) p20 domain. Arabidopsis contains three type I MCP genes (MCP1a-c) and six type II MCP genes (MCP2a#Aeif): AtMCP1a/At5g64240, AtMCP1b/At1g02170, AtMCP1c/At4g25110, AtMCP2a/At1g79310, AtMCP2b/At1g79330, AtMCP2c/At1g79320, AtMCP2d/At1g79340, AtMCP2e/At1g16420, AtMCP2f/At5g04200.
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Genomic context

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See MC5 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
2
Sequence:
Chromosome: 1; NC_003070.9 (29838551..29840317)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene metacaspase 7 Neighboring gene metacaspase 6 Neighboring gene miscRNA Neighboring gene metacaspase 4 Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene organic cation/carnitine transporter 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterising the Gene Expression, Enzymatic Activity and Subcellular Localisation of Arabidopsis thaliana Metacaspase 5 (AtMCA-IIb). Sobri ZM, et al. Biology (Basel), 2023 Aug 22. PMID 37759555, Free PMC Article
  2. Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast. Watanabe N, et al. J Biol Chem, 2005 Apr 15. PMID 15691845
  3. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases with roles in apoptosis. [AtMCP2b]
    Title: Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast.
Submit: New GeneRIF Correction

General gene information

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NM_106581.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of programmed cell death IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metacaspase 5
NP_178051.1
  • metacaspase 5 (MC5); FUNCTIONS IN: cysteine-type endopeptidase activity; INVOLVED IN: induction of apoptosis; LOCATED IN: chloroplast; EXPRESSED IN: root; CONTAINS InterPro DOMAIN/s: Peptidase C14, caspase catalytic (InterPro:IPR011600); BEST Arabidopsis thaliana protein match is: metacaspase 4 (TAIR:AT1G79340.1); Has 1246 Blast hits to 1206 proteins in 288 species: Archae - 3; Bacteria - 374; Metazoa - 2; Fungi - 283; Plants - 322; Viruses - 0; Other Eukaryotes - 262 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    29838551..29840317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106581.3 → NP_178051.1  metacaspase 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178051.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64518
    UniProtKB/TrEMBL
    A0A178WIC7, A0A5S9WVR7, A0A654F185
    Conserved Domains (1) summary
    pfam00656
    Location:3 → 170
    Peptidase_C14; Caspase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O64518.1

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