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Fmo3 flavin containing dimethylaniline monoxygenase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84493, updated on 27-Nov-2024

Summary

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Official Symbol
Fmo3provided by RGD
Official Full Name
flavin containing dimethylaniline monoxygenase 3provided by RGD
Primary source
RGD:619761
See related
EnsemblRapid:ENSRNOG00000003620 AllianceGenome:RGD:619761
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables N,N-dimethylaniline monooxygenase activity; NADP binding activity; and amino acid binding activity. Involved in xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to human FMO3 (flavin containing dimethylaniline monoxygenase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 845.6), Liver (RPKM 691.8) and 3 other tissues See more
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Genomic context

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See Fmo3 in Genome Data Viewer
Location:
13q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (77838899..77868869, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (75309367..75334915, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80837418..80856214, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481523 Neighboring gene flavin containing monooxygenase 6 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene maestro heat-like repeat family member 9 Neighboring gene 40S ribosomal protein S8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes. Novick RM, et al. Drug Metab Dispos, 2008 Dec. PMID 18775983, Free PMC Article
  2. Oxidative metabolism of seleno-L-methionine to L-methionine selenoxide by flavin-containing monooxygenases. Krause RJ, et al. Chem Res Toxicol, 2006 Dec. PMID 17173378, Free PMC Article
  3. Cloning, sequencing, tissue distribution, and heterologous expression of rat flavin-containing monooxygenase 3. Lattard V, et al. Arch Biochem Biophys, 2001 Jul 1. PMID 11414682
  4. Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians. Dolan C, et al. BMC Med Genet, 2005 Dec 2. PMID 16324215, Free PMC Article
  5. Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney. Lattard V, et al. Biochem Pharmacol, 2002 Apr 15. PMID 11996886

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes.
    Title: Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.
  2. Results demonstrate many similar properties between rat hepatic and renal FMO3 forms and suggest that renal FMO3 may play an important role in kidney metabolism of xenobiotics containing sulfur and selenium atoms.
    Title: Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes.
  3. the relationship between gender and development in the expression of FMO3 in the liver and kidney was determined
    Title: Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93304

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N,N-dimethylaniline monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N,N-dimethylaniline monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables albendazole monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables amino acid binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables hypotaurine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables hypotaurine monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity TAS
Traceable Author Statement
more info
 PubMed 
enables trimethylamine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in taurine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in taurine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
flavin-containing monooxygenase 3
Names
FMO 3
dimethylaniline monooxygenase [N-oxide-forming] 3
dimethylaniline oxidase 3
flavin containing monooxygenase 3
hepatic flavin-containing monooxygenase 3
trimethylamine monooxygenase
NP_445885.2
XP_038947055.1
XP_038947056.1
XP_063128721.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053433.2 → NP_445885.2  flavin-containing monooxygenase 3

    See identical proteins and their annotated locations for NP_445885.2

    Status: PROVISIONAL

    Source sequence(s)
    BC087008
    UniProtKB/Swiss-Prot
    Q5PQV6, Q9EQ76
    UniProtKB/TrEMBL
    A0A0G2JSI0, A6IDB5
    Related
    ENSRNOP00000004864.4, ENSRNOT00000004864.7
    Conserved Domains (1) summary
    pfam00743
    Location:2 → 530
    FMO-like; Flavin-binding monooxygenase-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    77838899..77868869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272651.1 → XP_063128721.1  flavin-containing monooxygenase 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSI0, A6IDB5

  2. XM_039091127.2 → XP_038947055.1  flavin-containing monooxygenase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5PQV6, Q9EQ76
    UniProtKB/TrEMBL
    A0A0G2JSI0, A6IDB5
    Conserved Domains (1) summary
    pfam00743
    Location:2 → 530
    FMO-like; Flavin-binding monooxygenase-like

  3. XM_039091128.2 → XP_038947056.1  flavin-containing monooxygenase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5PQV6, Q9EQ76
    UniProtKB/TrEMBL
    A0A0G2JSI0, A6IDB5
    Conserved Domains (1) summary
    pfam00743
    Location:2 → 530
    FMO-like; Flavin-binding monooxygenase-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQ76.1 GenPept UniProtKB/Swiss-Prot:Q9EQ76

Gene LinkOut

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