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Trpc4 transient receptor potential cation channel, subfamily C, member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84494, updated on 4-Jan-2025

Summary

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Official Symbol
Trpc4provided by RGD
Official Full Name
transient receptor potential cation channel, subfamily C, member 4provided by RGD
Primary source
RGD:621276
See related
EnsemblRapid:ENSRNOG00000011133 AllianceGenome:RGD:621276
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Trp4; Trrp4
Summary
Enables calcium channel activity. Involved in calcium ion transport; positive regulation of store-operated calcium entry; and regulation of action potential firing rate. Located in plasma membrane. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 49.8), Uterus (RPKM 18.0) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trpc4 in Genome Data Viewer
Location:
2q26
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (140457841..140629556)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (138307676..138476856)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (143433102..143605757)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-fold modifier 1 Neighboring gene uncharacterized LOC102549721 Neighboring gene uncharacterized LOC134485914 Neighboring gene periostin Neighboring gene dual specificity phosphatase 14-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Stretch-induced TRPC4 downregulation is accompanied by reduced capacitative Ca2+ entry in WKY but not SHR mesenteric smooth muscle cells. Lindsey SH, et al. Clin Exp Hypertens, 2010. PMID 20662729
  2. Cloning and expression localization of cDNA for rat homolog of TRP protein, a possible store-operated calcium (Ca2+) channel. Funayama M, et al. Brain Res Mol Brain Res, 1996 Dec 31. PMID 9037541
  3. Cloning and functional expression of a novel splice variant of rat TRPC4. Satoh E, et al. Circ J, 2002 Oct. PMID 12381092
  4. TRPC4 in rat dorsal root ganglion neurons is increased after nerve injury and is necessary for neurite outgrowth. Wu D, et al. J Biol Chem, 2008 Jan 4. PMID 17928298
  5. Cyclic stretch decreases TRPC4 protein and capacitative calcium entry in rat vascular smooth muscle cells. Lindsey SH, et al. Life Sci, 2008 Jul 4. PMID 18538797

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis.
    Title: TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis.
  2. STIM1L/Orai1/TRPC1/C4-dependent Ca(2+) current participates in Ca(2+) remodeling in right ventricular hypertrophy secondary to pulmonary hypertension.
    Title: Ca(2+) handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.
  3. In the trigeminal ganglion (TG), 56.1, 84.1, and 68.3% of sensory neurons were immunoreactive (IR) for TRPC1, TRPC3, and TRPC4, respectively.
    Title: TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures.
  4. 1) TRPC1/4 exert protective effects against SAH-induecd EBI, including cortical cell death and degenerating; 2) TRPC1/4 positively regulated the activity of calcineurin. 3) TRPC1/4 promoted the dephosphorylation of NMDAR via calcineurin.
    Title: Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation.
  5. The data of this study demonstrated a potentially novel role for TRPC4 channels in dopamine systems and may offer a new pharmacological target for more effective treatment of a variety of dopamine disorders.
    Title: Loss of the trpc4 gene is associated with a reduction in cocaine self-administration and reduced spontaneous ventral tegmental area dopamine neuronal activity, without deficits in learning for natural rewards.
  6. Our results show that TRPC4 underlies an exaggerated endothelial permeability response in pulmonary arterial hypertension
    Title: Transient Receptor Potential Channel 4 Encodes a Vascular Permeability Defect and High-Frequency Ca(2+) Transients in Severe Pulmonary Arterial Hypertension.
  7. Aldosterone specifically increased the mRNA and/or protein levels of Orai1, TRPC1, -C4, -C5, and stromal interaction molecule 1 through mineralocorticoid receptor activation
    Title: Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES.
  8. data provide evidence that TRPC4 is required for detection and/or transmission of colonic mustard oil visceral pain sensation
    Title: A rat knockout model implicates TRPC4 in visceral pain sensation.
  9. Hypertrophic response is dependent on the TrpC4alpha splice variant-specific sequence that binds to PIP2.
    Title: The phosphatidylinositol(4,5)bisphosphate-binding sequence of transient receptor potential channel canonical 4α is critical for its contribution to cardiomyocyte hypertrophy.
  10. TRPC4 inactivation therefore provides a survival benefit in severe PAH, associated with a decrease in the magnitude of occlusive remodeling.
    Title: TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol 1,4,5 trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables store-operated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables store-operated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in calcium ion import IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion import ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-aminobutyric acid secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of store-operated calcium entry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of action potential firing rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of calcium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in caveola IEA
Inferred from Electronic Annotation
more info
  
located_in caveola ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cortical cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
short transient receptor potential channel 4
Names
CCE1
capacitative calcium entry channel 1
transient receptor potential channel 4
transient receptor potential protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083115.1 → NP_001076584.1  short transient receptor potential channel 4 isoform beta

    See identical proteins and their annotated locations for NP_001076584.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (beta) has multiple differences in the coding region but maintains the reading frame, compared to variant alpha. This variant encodes isoform beta, which is shorter than isoform alpha.
    Source sequence(s)
    AF421364
    UniProtKB/Swiss-Prot
    O35119, Q91ZL9, Q9EQ74, Q9EQ75
    UniProtKB/TrEMBL
    A6JVB2, F7F3R3, Q91ZM0
    Related
    ENSRNOP00000015437.4, ENSRNOT00000015437.7
    Conserved Domains (2) summary
    TIGR00870
    Location:17 → 749
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:122 → 167
    ANK; ANK repeat [structural motif]

  2. NM_080396.1 → NP_536321.1  short transient receptor potential channel 4 isoform alpha

    See identical proteins and their annotated locations for NP_536321.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (alpha) encodes the longer isoform (alpha).
    Source sequence(s)
    AF421363
    UniProtKB/Swiss-Prot
    O35119, Q91ZL9, Q9EQ74, Q9EQ75
    UniProtKB/TrEMBL
    F7FEC4, Q91ZM1
    Related
    ENSRNOP00000094229.2, ENSRNOT00000101369.2
    Conserved Domains (4) summary
    cd00204
    Location:64 → 168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:17 → 749
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:176 → 235
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:122 → 167
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    140457841..140629556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103271.2 → XP_038959199.1  short transient receptor potential channel 4 isoform X3

    UniProtKB/Swiss-Prot
    O35119, Q91ZL9, Q9EQ74, Q9EQ75
    Conserved Domains (2) summary
    TIGR00870
    Location:17 → 749
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:122 → 167
    ANK; ANK repeat [structural motif]

  2. XM_017591143.3 → XP_017446632.1  short transient receptor potential channel 4 isoform X2

    UniProtKB/Swiss-Prot
    O35119, Q91ZL9, Q9EQ74, Q9EQ75
    UniProtKB/TrEMBL
    A6JVB2, F7F3R3, Q91ZM0
    Conserved Domains (2) summary
    TIGR00870
    Location:17 → 749
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:122 → 167
    ANK; ANK repeat [structural motif]

  3. XM_006232356.5 → XP_006232418.1  short transient receptor potential channel 4 isoform X1

    See identical proteins and their annotated locations for XP_006232418.1

    UniProtKB/Swiss-Prot
    O35119, Q91ZL9, Q9EQ74, Q9EQ75
    UniProtKB/TrEMBL
    F7FEC4, Q91ZM1
    Related
    ENSRNOP00000042886.2, ENSRNOT00000044028.5
    Conserved Domains (4) summary
    cd00204
    Location:64 → 168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:17 → 749
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:176 → 235
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:122 → 167
    ANK; ANK repeat [structural motif]

  4. XM_039103272.2 → XP_038959200.1  short transient receptor potential channel 4 isoform X4

    UniProtKB/TrEMBL
    A6JVB3, A6JVB4
    Conserved Domains (1) summary
    TIGR00870
    Location:1 → 329
    trp; transient-receptor-potential calcium channel protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_053434.1: Suppressed sequence

    Description
    NM_053434.1: This RefSeq was permanently suppressed because it contains a frameshift and is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35119.2 GenPept UniProtKB/Swiss-Prot:O35119

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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