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Rnf103 ring finger protein 103 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84508, updated on 4-Jan-2025

Summary

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Official Symbol
Rnf103provided by RGD
Official Full Name
ring finger protein 103provided by RGD
Primary source
RGD:620586
See related
EnsemblRapid:ENSRNOG00000007272 AllianceGenome:RGD:620586
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kf1; Adrg34; Zfp103
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in ERAD pathway and protein ubiquitination. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Used to study depressive disorder. Orthologous to human RNF103 (ring finger protein 103). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 258.7), Kidney (RPKM 160.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf103 in Genome Data Viewer
Location:
4q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (105084762..105100839)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (103526456..103542529)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99398479..99415193)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene CD8 subunit alpha Neighboring gene transfer RNA serine (anticodon AGA) 32 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene charged multivesicular body protein 3 Neighboring gene lysine demethylase 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel gene with RING-H2 finger motif induced after chronic antidepressant treatment in rat brain. Yamada M, et al. Biochem Biophys Res Commun, 2000 Nov 11. PMID 11071867
  2. Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway. Maruyama Y, et al. Biochem Biophys Res Commun, 2008 Oct 3. PMID 18675248
  3. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Lorick KL, et al. Proc Natl Acad Sci U S A, 1999 Sep 28. PMID 10500182, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF103
Names
RING-type E3 ubiquitin transferase RNF103
zfp-103
zinc finger protein 103
NP_445890.2
XP_006236715.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053438.2 → NP_445890.2  E3 ubiquitin-protein ligase RNF103

    See identical proteins and their annotated locations for NP_445890.2

    Status: PROVISIONAL

    Source sequence(s)
    BC100629
    UniProtKB/Swiss-Prot
    Q9EPZ8
    UniProtKB/TrEMBL
    Q497B6
    Related
    ENSRNOP00000089357.2, ENSRNOT00000108994.2
    Conserved Domains (1) summary
    cd16473
    Location:618 → 663
    RING-H2_RNF103; RING finger, H2 subclass, found in RING finger protein 103 (RNF103) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    105084762..105100839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236653.5 → XP_006236715.1  E3 ubiquitin-protein ligase RNF103 isoform X1

    UniProtKB/Swiss-Prot
    Q9EPZ8
    Conserved Domains (1) summary
    cd00162
    Location:623 → 666
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPZ8.1 GenPept UniProtKB/Swiss-Prot:Q9EPZ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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