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TTF2 transcription termination factor 2 [ Homo sapiens (human) ]

Gene ID: 8458, updated on 27-Nov-2024

Summary

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Official Symbol
TTF2provided by HGNC
Official Full Name
transcription termination factor 2provided by HGNC
Primary source
HGNC:HGNC:12398
See related
Ensembl:ENSG00000116830 MIM:604718; AllianceGenome:HGNC:12398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F2; HuF2; ZGRF6
Summary
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Annotation information
Note: TTF2 (Gene ID: 8458) and FOXE1 (Gene ID: 2304) share the TTF2 symbol/alias in common. TTF2 is a widely used alternative name for forkhead box E1 (FOXE1), which can be confused with the official symbol for transcription termination factor 2 (TTF2). [31 May 2018]
Expression
Ubiquitous expression in lymph node (RPKM 3.1), appendix (RPKM 2.5) and 25 other tissues See more
Orthologs
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Genomic context

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See TTF2 in Genome Data Viewer
Location:
1p13.1
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (117060326..117107453)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (117070767..117117876)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (117602948..117650075)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CD101 molecule Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:117560254-117561453 Neighboring gene uncharacterized LOC124904386 Neighboring gene CD101 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1579 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:117619501-117620700 Neighboring gene microRNA 942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1580 Neighboring gene tripartite motif containing 45 Neighboring gene uncharacterized LOC124904387 Neighboring gene ribosomal protein S15a pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer. Hara R, et al. J Biol Chem, 1999 Aug 27. PMID 10455150
  2. Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. Jiang Y, et al. Mol Cell, 2004 May 7. PMID 15125840
  3. Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector. Jiang Y, et al. Cell Cycle, 2004 Sep. PMID 15467445
  4. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. Liu M, et al. J Biol Chem, 1998 Oct 2. PMID 9748214
  5. Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein. Girdham CH, et al. Genes Dev, 1991 Oct. PMID 1916263

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TTF2 is the only ATP-dependent termination activity associated with Pol II transcription elongation complexes, is largely unaffected by template position, and is impervious to the phosphorylation state of the polymerase.
    Title: Involvement of transcription termination factor 2 in mitotic repression of transcription elongation.
  2. Importantly, the mitotic phenotype seen with TTF2-siRNA is rescued by expression of the siRNA-resistant GFP-tagged TTF2 proving that reduced TTF2 is responsible for the retention of RNA polymerase II on mitotic chromosomes.
    Title: Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector.
  3. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing
    Title: hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Depletion of transcription termination factor, RNA polymerase II (TTF2) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated transcription termination TAS
Traceable Author Statement
more info
 PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription elongation factor complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
transcription termination factor 2
Names
RNA polymerase II termination factor
human factor 2
lodestar homolog
lodestar protein
transcription release factor 2
transcription termination factor, RNA polymerase II
zinc finger, GRF-type containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003594.4 → NP_003585.3  transcription termination factor 2

    See identical proteins and their annotated locations for NP_003585.3

    Status: REVIEWED

    Source sequence(s)
    AF073771, AF080255, AI991355, AL391476, AL445231, AW027795, BC030058, BI857056, BQ422564, BU182600, H81916
    Consensus CDS
    CCDS892.1
    UniProtKB/Swiss-Prot
    A8K4Q2, O75921, Q5T2K7, Q5VVU8, Q8N6I8, Q9UNY4
    Related
    ENSP00000358478.3, ENST00000369466.9
    Conserved Domains (4) summary
    cd00046
    Location:590 → 768
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:573 → 933
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:990 → 1106
    Helicase_C; Helicase conserved C-terminal domain
    pfam06839
    Location:4 → 39
    zf-GRF; GRF zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    117060326..117107453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002552.3 → XP_016858041.1  transcription termination factor 2 isoform X2

  2. XM_017002550.3 → XP_016858039.1  transcription termination factor 2 isoform X1

  3. XM_017002551.3 → XP_016858040.1  transcription termination factor 2 isoform X1

  4. XM_047432141.1 → XP_047288097.1  transcription termination factor 2 isoform X5

  5. XM_047432143.1 → XP_047288099.1  transcription termination factor 2 isoform X5

  6. XM_047432144.1 → XP_047288100.1  transcription termination factor 2 isoform X6

  7. XM_047432147.1 → XP_047288103.1  transcription termination factor 2 isoform X6

  8. XM_047432135.1 → XP_047288091.1  transcription termination factor 2 isoform X3

  9. XM_047432136.1 → XP_047288092.1  transcription termination factor 2 isoform X3

  10. XM_017002555.3 → XP_016858044.1  transcription termination factor 2 isoform X7

    UniProtKB/Swiss-Prot
    A8K4Q2, O75921, Q5T2K7, Q5VVU8, Q8N6I8, Q9UNY4
    Conserved Domains (4) summary
    cd00046
    Location:590 → 768
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:573 → 933
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:990 → 1106
    Helicase_C; Helicase conserved C-terminal domain
    pfam06839
    Location:4 → 39
    zf-GRF; GRF zinc finger

  11. XM_047432152.1 → XP_047288108.1  transcription termination factor 2 isoform X7

    UniProtKB/Swiss-Prot
    A8K4Q2, O75921, Q5T2K7, Q5VVU8, Q8N6I8, Q9UNY4

  12. XM_047432139.1 → XP_047288095.1  transcription termination factor 2 isoform X4

  13. XM_047432155.1 → XP_047288111.1  transcription termination factor 2 isoform X8

  14. XM_047432157.1 → XP_047288113.1  transcription termination factor 2 isoform X8

  15. XM_047432161.1 → XP_047288117.1  transcription termination factor 2 isoform X9

  16. XM_047432162.1 → XP_047288118.1  transcription termination factor 2 isoform X10

RNA

  1. XR_007064424.1 RNA Sequence

  2. XR_007064425.1 RNA Sequence

  3. XR_007064426.1 RNA Sequence

  4. XR_007064427.1 RNA Sequence

  5. XR_007064429.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    117070767..117117876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339201.1 → XP_054195176.1  transcription termination factor 2 isoform X1

  2. XM_054339202.1 → XP_054195177.1  transcription termination factor 2 isoform X1

  3. XM_054339207.1 → XP_054195182.1  transcription termination factor 2 isoform X5

  4. XM_054339208.1 → XP_054195183.1  transcription termination factor 2 isoform X5

  5. XM_054339203.1 → XP_054195178.1  transcription termination factor 2 isoform X2

  6. XM_054339209.1 → XP_054195184.1  transcription termination factor 2 isoform X6

  7. XM_054339210.1 → XP_054195185.1  transcription termination factor 2 isoform X6

  8. XM_054339204.1 → XP_054195179.1  transcription termination factor 2 isoform X3

  9. XM_054339205.1 → XP_054195180.1  transcription termination factor 2 isoform X3

  10. XM_054339211.1 → XP_054195186.1  transcription termination factor 2 isoform X7

  11. XM_054339212.1 → XP_054195187.1  transcription termination factor 2 isoform X7

  12. XM_054339206.1 → XP_054195181.1  transcription termination factor 2 isoform X4

  13. XM_054339213.1 → XP_054195188.1  transcription termination factor 2 isoform X8

  14. XM_054339214.1 → XP_054195189.1  transcription termination factor 2 isoform X8

  15. XM_054339215.1 → XP_054195190.1  transcription termination factor 2 isoform X9

  16. XM_054339216.1 → XP_054195191.1  transcription termination factor 2 isoform X10

RNA

  1. XR_008486180.1 RNA Sequence

  2. XR_008486181.1 RNA Sequence

  3. XR_008486182.1 RNA Sequence

  4. XR_008486183.1 RNA Sequence

  5. XR_008486184.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UNY4.2 GenPept UniProtKB/Swiss-Prot:Q9UNY4

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