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ZNF587 zinc finger protein 587 [ Homo sapiens (human) ]

Gene ID: 84914, updated on 27-Nov-2024

Summary

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Official Symbol
ZNF587provided by HGNC
Official Full Name
zinc finger protein 587provided by HGNC
Primary source
HGNC:HGNC:30955
See related
Ensembl:ENSG00000198466 AllianceGenome:HGNC:30955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZF6
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in prostate (RPKM 5.4), duodenum (RPKM 5.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF587 in Genome Data Viewer
Location:
19q13.43
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57849859..57865117)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60946766..60962029)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58361227..58376485)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase 1A pseudogene 1 Neighboring gene zinc finger protein 587B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15167 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:58361669-58362868 Neighboring gene uncharacterized LOC124904782 Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 5 Neighboring gene zinc finger protein 814 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:58398549-58399281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58399306-58399849 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58399850-58400392

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MiRNA-4537 functions as a tumor suppressor in gastric cancer and increases the radiosensitivity of gastric cancer cells. Liu J, et al. Bioengineered, 2021 Dec. PMID 34670480, Free PMC Article
  2. The long non-sacoding RNA TMEM147-AS1/miR-133b/ZNF587 axis regulates the Warburg effect and promotes prostatic carcinoma invasion and proliferation. Wu T, et al. J Gene Med, 2022 Nov. PMID 36181243
  3. Computer sequence analysis of human highly conserved zinc finger modules. Petroni D, et al. DNA Seq, 1998. PMID 10520746
  4. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
  5. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The long non-sacoding RNA TMEM147-AS1/miR-133b/ZNF587 axis regulates the Warburg effect and promotes prostatic carcinoma invasion and proliferation.
    Title: The long non-sacoding RNA TMEM147-AS1/miR-133b/ZNF587 axis regulates the Warburg effect and promotes prostatic carcinoma invasion and proliferation.
  2. MiRNA-4537 functions as a tumor suppressor in gastric cancer and increases the radiosensitivity of gastric cancer cells.
    Title: MiRNA-4537 functions as a tumor suppressor in gastric cancer and increases the radiosensitivity of gastric cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 587 (ZNF587) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14710, FLJ20813, FLJ52732

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 587
Names
zinc finger protein zfp6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204817.2 → NP_001191746.1  zinc finger protein 587 isoform 2

    See identical proteins and their annotated locations for NP_001191746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AA524202, AC010326, BC144112, DA334859
    Consensus CDS
    CCDS56110.1
    UniProtKB/Swiss-Prot
    Q96SQ5
    Related
    ENSP00000393865.1, ENST00000423137.1
    Conserved Domains (5) summary
    smart00349
    Location:14 → 69
    KRAB; krueppel associated box
    COG5048
    Location:272 → 567
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:353 → 373
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:533 → 556
    zf-H2C2_2; Zinc-finger double domain

  2. NM_032828.4 → NP_116217.1  zinc finger protein 587 isoform 1

    See identical proteins and their annotated locations for NP_116217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA524202, AC010326, BC126239, DA334859
    Consensus CDS
    CCDS12964.1
    UniProtKB/Swiss-Prot
    A0AV72, G3V0H5, Q6ZMK8, Q96SQ5
    Related
    ENSP00000345479.4, ENST00000339656.8
    Conserved Domains (5) summary
    smart00349
    Location:15 → 70
    KRAB; krueppel associated box
    COG5048
    Location:273 → 568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:354 → 374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 54
    KRAB; KRAB box
    pfam13465
    Location:534 → 557
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57849859..57865117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60946766..60962029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017961.3: Suppressed sequence

    Description
    NM_017961.3: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96SQ5.1 GenPept UniProtKB/Swiss-Prot:Q96SQ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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