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VBA3 basic amino acid transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 850290, updated on 4-Jan-2025

Summary

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Official Symbol
VBA3
Official Full Name
basic amino acid transporter
Primary source
SGD:S000000574
Locus tag
YCL069W
See related
AllianceGenome:SGD:S000000574; FungiDB:YCL069W; VEuPathDB:YCL069W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transport and transmembrane transport. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See VBA3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (9706..11082)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene glutathione exchanger Neighboring gene uncharacterized protein Neighboring gene homeodomain mating type protein alpha2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. Shimazu M, et al. J Biol Chem, 2005 Feb 11. PMID 15572352
  2. Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Katju V, et al. Genome Biol, 2009. PMID 19594930, Free PMC Article
  3. The complete DNA sequence of yeast chromosome III. Oliver SG, et al. Nature, 1992 May 7. PMID 1574125
  4. Large-scale identification of yeast integral membrane protein interactions. Miller JP, et al. Proc Natl Acad Sci U S A, 2005 Aug 23. PMID 16093310, Free PMC Article
  5. Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes. Espinosa-Cantú A, et al. Genetics, 2018 Jan. PMID 29127264, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables basic amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables basic amino acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in basic amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in basic amino acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
basic amino acid transporter
NP_009864.1
  • Permease of basic amino acids in the vacuolar membrane; VBA3 has a paralog, VBA5, that arose from a segmental duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    9706..11082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178710.1 → NP_009864.1  TPA: basic amino acid transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009864.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQV0, P25594
    UniProtKB/TrEMBL
    A7A064
    Conserved Domains (1) summary
    cl28910
    Location:1 → 369
    MFS; Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25594.1

Gene LinkOut

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