CHA1 L-serine/L-threonine ammonia-lyase CHA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CHA1
Official Full Name: L-serine/L-threonine ammonia-lyase CHA1
Primary source: SGD:S000000569
Locus tag: YCL064C
See related: AllianceGenome:SGD:S000000569; FungiDB:YCL064C; VEuPathDB:YCL064C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables L-serine ammonia-lyase activity and threonine deaminase activity. Involved in L-serine catabolic process and threonine catabolic process. Located in mitochondrial nucleoid. Orthologous to human SDS (serine dehydratase) and SDSL (serine dehydratase like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CHA1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (15798..16880, complement)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

serine induces CHA1 through driving de novo synthesis of sphingolipids.
Title: Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability.
Six mutations in H3 cause significant derepression of the CHA1 promoter.
Title: Dispersed mutations in histone H3 that affect transcriptional repression and chromatin structure of the CHA1 promoter in Saccharomyces cerevisiae.
Mediator is required for recruitment of the transcription machinery subsequent to chromatin remodeling during CHA1 induction.
Title: Mediator requirement downstream of chromatin remodeling during transcriptional activation of CHA1 in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables L-serine ammonia-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-serine ammonia-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-serine ammonia-lyase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables threonine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables threonine deaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-serine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in threonine catabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: L-serine/L-threonine ammonia-lyase CHA1

NP_001018030.1

EC 4.3.1.17

EC 4.3.1.19

Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

15798..16880 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178706.1 → NP_001018030.1 TPA: L-serine/L-threonine ammonia-lyase CHA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_001018030.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQV4, P25379

UniProtKB/TrEMBL

A6ZTD3, B3LU22, C7GT17, C8Z427, G2W9W5, N1P7Z9

Conserved Domains (1) summary

cd06448
Location:7 → 333

L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.