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PEX34 Pex34p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850302, updated on 4-Jan-2025

Summary

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Official Symbol
PEX34
Official Full Name
Pex34p
Primary source
SGD:S000000561
Locus tag
YCL056C
See related
AllianceGenome:SGD:S000000561; FungiDB:YCL056C; VEuPathDB:YCL056C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables peroxisome-mitochondrion membrane tether activity. Involved in peroxisome organization. Located in peroxisomal membrane. Is active in peroxisomal-mitochondrial contact site. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PEX34 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (26925..27359, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Mic10p Neighboring gene metalloendopeptidase Neighboring gene Kar4p Neighboring gene Rdt1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of peroxisomes in xylose alcoholic fermentation in the engineered Saccharomyces cerevisiae. Dzanaeva L, et al. Cell Biol Int, 2020 Aug. PMID 32227552
  2. The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast. Tower RJ, et al. Mol Biol Cell, 2011 May 15. PMID 21441307, Free PMC Article
  3. Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p. Chalermwat C, et al. FEMS Yeast Res, 2019 Dec 1. PMID 31711143, Free PMC Article
  4. Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact. Shai N, et al. Nat Commun, 2018 May 2. PMID 29720625, Free PMC Article
  5. Genetic Analysis of Peroxisomal Genes Required for Longevity in a Yeast Model of Citrin Deficiency. Chalermwat C, et al. Diseases, 2020 Jan 9. PMID 31936501, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p
    Title: Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p.
  2. discovery of Pex34p as a protein involved in the already complex control of peroxisome populations emphasizes the necessity of cells to strictly regulate their peroxisome populations. [pex34p]
    Title: The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables peroxisome-mitochondrion membrane tether activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in peroxisome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peroxisome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal-mitochondrial contact site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pex34p
NP_009875.1
  • Protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation; mediates contacts between mitochondria and peroxisomes that stimulate transport of citrate, converted from acetyl-CoA, from peroxisomes to mitochondria; peroxisomal integral membrane protein that is enriched at peroxisomal-mitochondrial (PerMit) contact sites

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    26925..27359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178700.1 → NP_009875.1  TPA: Pex34p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009875.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQW1, P25584
    UniProtKB/TrEMBL
    A6ZTD9, B3LU29, C7GT10, C8Z435, G2W9X2, N1P7P2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25584.1

Gene LinkOut

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