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GID7 glucose-induced degradation complex subunit GID7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850318, updated on 2-Nov-2024

Summary

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Official Symbol
GID7
Official Full Name
glucose-induced degradation complex subunit GID7
Primary source
SGD:S000000544
Locus tag
YCL039W
See related
AllianceGenome:SGD:S000000544; FungiDB:YCL039W; VEuPathDB:YCL039W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MOH2
Summary
Involved in negative regulation of gluconeogenesis and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in peroxisome. Part of GID complex. Orthologous to human WDR26 (WD repeat domain 26). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GID7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (52645..54882)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase PDI1 Neighboring gene uncharacterized protein Neighboring gene glucokinase Neighboring gene Atg22p Neighboring gene Sro9p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of genes affecting glucose catabolism in nitrogen-limited fermentation. Gardner JM, et al. FEMS Yeast Res, 2005 Jun. PMID 15925307
  2. Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. Menssen R, et al. J Biol Chem, 2012 Jul 20. PMID 22645139, Free PMC Article
  3. Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Qiao S, et al. Nat Commun, 2022 Jun 1. PMID 35650207, Free PMC Article
  4. The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism. Santt O, et al. Mol Biol Cell, 2008 Aug. PMID 18508925, Free PMC Article
  5. Effects of mutations of GID protein-coding genes on malate production and enzyme expression profiles in Saccharomyces cerevisiae. Negoro H, et al. Appl Microbiol Biotechnol, 2020 Jun. PMID 32248437

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GID complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glucose-induced degradation complex subunit GID7
NP_009891.1
  • Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; localizes to peroxisomes in oleate-growing cells; computational analysis suggests that Gid7p and Moh1p have similar functions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    52645..54882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178684.1 → NP_009891.1  TPA: glucose-induced degradation complex subunit GID7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009891.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQX6, P25569
    UniProtKB/TrEMBL
    A6ZTF1, B5VES1, N1PAP0
    Conserved Domains (2) summary
    sd00039
    Location:327 → 369
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:318 → 741
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25569.2

Gene LinkOut

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