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MXR2 peptide-methionine (R)-S-oxide reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850324, updated on 4-Jan-2025

Summary

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Official Symbol
MXR2
Official Full Name
peptide-methionine (R)-S-oxide reductase
Primary source
SGD:S000000538
Locus tag
YCL033C
See related
AllianceGenome:SGD:S000000538; FungiDB:YCL033C; VEuPathDB:YCL033C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables peptide-methionine (R)-S-oxide reductase activity. Involved in cellular response to oxidative stress. Located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to several human genes including MSRB2 (methionine sulfoxide reductase B2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MXR2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (62776..63282, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene dithiol glutaredoxin GRX1 Neighboring gene Lsb5p Neighboring gene Ste50p Neighboring gene Rrp7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reverse genetic approaches in plants and yeast suggest a role for novel, evolutionarily conserved, selenoprotein-related genes in oxidative stress defense. Rodrigo MJ, et al. Mol Genet Genomics, 2002 Jul. PMID 12172800
  2. CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function. Fomenko DE, et al. Protein Sci, 2002 Oct. PMID 12237451, Free PMC Article
  3. Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Koc A, et al. Proc Natl Acad Sci U S A, 2004 May 25. PMID 15141092, Free PMC Article
  4. A conserved R type Methionine Sulfoxide Reductase reverses oxidized GrpEL1/Mge1 to regulate Hsp70 chaperone cycle. Allu PK, et al. Sci Rep, 2018 Feb 9. PMID 29426933, Free PMC Article
  5. Methionine sulfoxide reductase 2 regulates Cvt autophagic pathway by altering the stability of Atg19 and Ape1 in Saccharomyces cerevisiae. Chatterjee A, et al. J Biol Chem, 2024 Mar. PMID 38246354, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors conclude that the Mxr2-Mge1-Hsp70 protein triad is finely regulated through structural alterations of Mge1 mediated by redox levels.
    Title: Adaptation of Mge1 to oxidative stress by local unfolding and altered Interaction with mitochondrial Hsp70 and Mxr2.
  2. Mxr2 regulates Mge1 by selectively reducing methionine sulfoxide at position 155 and restores the activity of Mge1 both in vitro and in vivo.
    Title: Methionine sulfoxide reductase 2 reversibly regulates Mge1, a cochaperone of mitochondrial Hsp70, during oxidative stress.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-methionine (R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein repair IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
peptide-methionine (R)-S-oxide reductase
NP_009897.1
  • Methionine-R-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    62776..63282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178678.1 → NP_009897.1  TPA: peptide-methionine (R)-S-oxide reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009897.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQY2, P25566
    UniProtKB/TrEMBL
    A6ZTF7, B3LU49, C7GSZ0, C8Z456, G2W9Z2, N1P7S1
    Conserved Domains (1) summary
    COG0229
    Location:31 → 168
    MsrB; Peptide methionine sulfoxide reductase MsrB [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25566.1

Gene LinkOut

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