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RER1 protein retrieval receptor [ Saccharomyces cerevisiae S288C ]

Gene ID: 850354, updated on 9-Dec-2024

Summary

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Official Symbol
RER1
Official Full Name
protein retrieval receptor
Primary source
SGD:S000000507
Locus tag
YCL001W
See related
AllianceGenome:SGD:S000000507; FungiDB:YCL001W; VEuPathDB:YCL001W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in COPI-coated vesicle; COPII-coated ER to Golgi transport vesicle; and fungal-type vacuole. Orthologous to human RER1 (retention in endoplasmic reticulum sorting receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RER1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (111916..112482)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kex2-dependent invertase secretion as a tool to study the targeting of transmembrane proteins which are involved in ER-->Golgi transport in yeast. Boehm J, et al. EMBO J, 1994 Aug 15. PMID 8070399, Free PMC Article
  2. Rer1p, a retrieval receptor for endoplasmic reticulum membrane proteins, is dynamically localized to the Golgi apparatus by coatomer. Sato K, et al. J Cell Biol, 2001 Mar 5. PMID 11238450, Free PMC Article
  3. Endoplasmic reticulum quality control of unassembled iron transporter depends on Rer1p-mediated retrieval from the golgi. Sato M, et al. Mol Biol Cell, 2004 Mar. PMID 14699055, Free PMC Article
  4. Rer1p, a retrieval receptor for ER membrane proteins, recognizes transmembrane domains in multiple modes. Sato K, et al. Mol Biol Cell, 2003 Sep. PMID 12972550, Free PMC Article
  5. Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain. Sato M, et al. J Cell Biol, 1996 Jul. PMID 8707815, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein retention in ER lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein retention in ER lumen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in COPI-coated vesicle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein retrieval receptor
NP_009925.1
  • Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    111916..112482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178651.1 → NP_009925.1  TPA: protein retrieval receptor [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009925.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR09, P25560
    UniProtKB/TrEMBL
    A6ZTI1, B3LU71, B5VEU9, C8Z483, G2WA17, N1PAP7
    Conserved Domains (1) summary
    COG5249
    Location:1 → 183
    RER1; Golgi protein involved in Golgi-to-ER retrieval [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25560.2

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