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ADY2 Ady2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850368, updated on 9-Dec-2024

Summary

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Official Symbol
ADY2
Official Full Name
Ady2p
Primary source
SGD:S000000603
Locus tag
YCR010C
See related
AllianceGenome:SGD:S000000603; FungiDB:YCR010C; VEuPathDB:YCR010C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ATO1
Summary
Enables acetate transmembrane transporter activity and ammonium channel activity. Involved in acetate transport; ammonium transmembrane transport; and nitrogen utilization. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ADY2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (132273..133124, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase SAT4 Neighboring gene amphiphysin-like protein RVS161 Neighboring gene putative ATP-dependent permease ADP1 Neighboring gene phosphoglycerate kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Architecture of developing multicellular yeast colony: spatio-temporal expression of Ato1p ammonium exporter. Váchová L, et al. Environ Microbiol, 2009 Jul. PMID 19302539
  2. New insights into the acetate uptake transporter (AceTr) family: Unveiling amino acid residues critical for specificity and activity. Rendulić T, et al. Comput Struct Biotechnol J, 2021. PMID 34471488, Free PMC Article
  3. Identification and application of keto acids transporters in Yarrowia lipolytica. Guo H, et al. Sci Rep, 2015 Jan 30. PMID 25633653, Free PMC Article
  4. Deletion of JEN1 and ADY2 reduces lactic acid yield from an engineered Saccharomyces cerevisiae, in xylose medium, expressing a heterologous lactate dehydrogenase. Turner TL, et al. FEMS Yeast Res, 2019 Sep 1. PMID 31505595
  5. Mutations at different sites in members of the Gpr1/Fun34/YaaH protein family cause hypersensitivity to acetic acid in Saccharomyces cerevisiae as well as in Yarrowia lipolytica. Gentsch M, et al. FEMS Yeast Res, 2007 May. PMID 17233767

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. deletion of SNF1 abolishes the increase of histone H3 acetylation at the promoter of the glucose-repressed ADY2 gene, and as a consequence profoundly affects the chromatin structural alterations accompanying transcriptional activation
    Title: Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S. cerevisiae ADY2 promoter.
  2. there is an interaction between molecules of the same Ato protein, namely Ato1p-Ato1p and Ato3p-Ato3p, but not Ato2p-Ato2p
    Title: Ato protein interactions in yeast plasma membrane revealed by fluorescence lifetime imaging (FLIM).
  3. study demonstrated that monocarboxylate transporters Jen1 and Ady2 are modulators of lactic acid production
    Title: Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2.
  4. The authors show that neighbouring microcolonies coordinate production of Ato1p-green fluorescent protein.
    Title: Architecture of developing multicellular yeast colony: spatio-temporal expression of Ato1p ammonium exporter.
  5. These data suggest that besides the ammonia induction of Ato protein synthesis, pH may rapidly regulate Ato1p function.
    Title: Association of putative ammonium exporters Ato with detergent-resistant compartments of plasma membrane during yeast colony development: pH affects Ato1p localisation in patches.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ammonium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in acetate transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ammonium transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ammonium transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrogen utilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ady2p
NP_009936.1
  • Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    132273..133124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178723.1 → NP_009936.1  TPA: Ady2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009936.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR19, P25613
    UniProtKB/TrEMBL
    A6ZTJ1, B3LU81, C7GQM2, C8Z497, G2WA27, N1P694
    Conserved Domains (1) summary
    pfam01184
    Location:71 → 276
    Grp1_Fun34_YaaH; GPR1/FUN34/yaaH family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25613.1

Gene LinkOut

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