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ACT1 actin [ Saccharomyces cerevisiae S288C ]

Gene ID: 850504, updated on 9-Dec-2024

Summary

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Official Symbol
ACT1
Official Full Name
actin
Primary source
SGD:S000001855
Locus tag
YFL039C
See related
AllianceGenome:SGD:S000001855; FungiDB:YFL039C; VEuPathDB:YFL039C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ABY1; END7
Summary
Enables ATP hydrolysis activity. A structural constituent of cytoskeleton. Involved in several processes, including ascospore wall assembly; mitotic actomyosin contractile ring contraction; and vacuole inheritance. Located in actin cytoskeleton. Part of Ino80 complex; NuA4 histone acetyltransferase complex; and Swr1 complex. Used to study Baraitser-Winter syndrome 1; artery disease (multiple); autosomal dominant nonsyndromic deafness 20; intestinal atresia; and patent ductus arteriosus. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; artery disease (multiple); congenital myopathy (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ACT1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
2
Sequence:
Chromosome: VI; NC_001138.5 (53260..54696, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene ferroxidase FET5 Neighboring gene uncharacterized protein Neighboring gene Rab family GTPase YPT1 Neighboring gene beta-tubulin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of the substitution of muscle actin-specific subdomain 1 and 2 residues in yeast actin on actin function. McKane M, et al. J Biol Chem, 2006 Oct 6. PMID 16882670
  2. His(73), often methylated, is an important structural determinant for actin. A mutagenic analysis of HIS(73) of yeast actin. Yao X, et al. J Biol Chem, 1999 Dec 24. PMID 10601317
  3. Role of the N-terminal negative charges of actin in force generation and cross-bridge kinetics in reconstituted bovine cardiac muscle fibres. Lu X, et al. J Physiol, 2005 Apr 1. PMID 15649975, Free PMC Article
  4. Differences in structural dynamics of muscle and yeast actin accompany differences in functional interactions with myosin. Prochniewicz E, et al. Biochemistry, 1999 Nov 9. PMID 10555968
  5. A highly conserved 3-methylhistidine modification is absent in yeast actin. Kalhor HR, et al. Arch Biochem Biophys, 1999 Oct 1. PMID 10496983

See all (570) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.
    Title: Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.
  2. Mechanical stiffness of reconstituted actin patches correlates tightly with endocytosis efficiency.
    Title: Mechanical stiffness of reconstituted actin patches correlates tightly with endocytosis efficiency.
  3. The authors show that the type-I myosins Myo3 and Myo5 promote, in a dose-dependent way, the growth and expansion of the actin network, which controls the speed of membrane and coat internalization.
    Title: Type-I myosins promote actin polymerization to drive membrane bending in endocytosis.
  4. Act1 protein affects tombusvirus recombination in yeast .
    Title: Screening a yeast library of temperature-sensitive mutants reveals a role for actin in tombusvirus RNA recombination.
  5. Using multi-color total internal reflection fluorescence microscopy, the study shows that Crn1 enhances Cof1-mediated severing by accelerating Cof1 binding to actin filament sides.
    Title: Coronin Enhances Actin Filament Severing by Recruiting Cofilin to Filament Sides and Altering F-Actin Conformation.
  6. Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2alpha phosphorylation.
    Title: Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2α phosphorylation.
  7. Heat shock-induced processing of actin assembly protein Lsb1 is involved in prion inheritance.
    Title: Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion.
  8. Data suggest that a glycolytic multi-enzyme complex assembles in cytoplasm of S. cerevisiae in association with F-actin (filamentous actin) but not in association with G-actin (monomeric globular actin).
    Title: A glycolytic metabolon in Saccharomyces cerevisiae is stabilized by F-actin.
  9. Lsb1 and/or Lsb2 full-length proteins inhibit Las17-mediated actin polymerization
    Title: Lsb1 is a negative regulator of las17 dependent actin polymerization involved in endocytosis.
  10. data suggest that the R256H actin mutation alters filament conformation resulting in filament instability and misregulation by formin
    Title: Thoracic aortic aneurysm (TAAD)-causing mutation in actin affects formin regulation of polymerization.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ascospore wall assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic actomyosin contractile ring contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Swr1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament bundle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membraneless organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
actin
NP_116614.1
  • Actin, structural protein in cytoskeleton; involved in cell polarization, endocytosis, and other cytoskeletal functions; monomeric actin in the nucleus plays a role in INO80 chromatin remodeling

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    53260..54696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179927.1 → NP_116614.1  TPA: actin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116614.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTJ1, P60010, Q9P3X6, Q9P3X7
    UniProtKB/TrEMBL
    A7A200, B3LUH2, C8Z7P3, E9P9M3, G2WDA2, N1PA17
    Conserved Domains (1) summary
    cl17037
    Location:1 → 375
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60010.1

Gene LinkOut

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