GCN20 putative AAA family ATPase GCN20 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GCN20
Official Full Name: putative AAA family ATPase GCN20
Primary source: SGD:S000001905
Locus tag: YFR009W
See related: AllianceGenome:SGD:S000001905; FungiDB:YFR009W; VEuPathDB:YFR009W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in regulation of translational elongation. Acts upstream of or within protein unfolding. Located in cytosolic ribosome. Orthologous to human ABCF3 (ATP binding cassette subfamily F member 3). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Frameshifting at collided ribosomes is modulated by elongation factor eEF3 and by integrated stress response regulators Gcn1 and Gcn20.
Title: Frameshifting at collided ribosomes is modulated by elongation factor eEF3 and by integrated stress response regulators Gcn1 and Gcn20.
Snf1 functions upstream of Gcn20 to regulate control of GCN4 translation in S. cerevisiae
Title: A chemical genomics study identifies Snf1 as a repressor of GCN4 translation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein unfolding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed

NP_116664.1

Positive regulator of the Gcn2p kinase activity; important for disaggregation of ordered and disordered protein aggregates; forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; suppresses frameshifting at stalled ribosomes

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The following sections contain reference sequences that belong to a specific genome build. Explain