ECO1 Eco1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ECO1
Official Full Name: Eco1p
Primary source: SGD:S000001923
Locus tag: YFR027W
See related: AllianceGenome:SGD:S000001923; FungiDB:YFR027W; VEuPathDB:YFR027W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CTF7
Summary: Enables acetyltransferase activity. Involved in several processes, including DNA metabolic process; chromatin looping; and chromosome organization. Acts upstream of or within establishment of meiotic sister chromatid cohesion. Located in nuclear replication fork. Used to study Roberts syndrome. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to human ESCO1 (establishment of sister chromatid cohesion N-acetyltransferase 1) and ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ECO1 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (207452..208297)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mistranslating tRNA identifies a deleterious S213P mutation in the Saccharomyces cerevisiae eco1-1 allele.
Title: Mistranslating tRNA identifies a deleterious S213P mutation in the Saccharomyces cerevisiaeeco1-1 allele.
Functional control of Eco1 through the MCM complex in sister chromatid cohesion.
Title: Functional control of Eco1 through the MCM complex in sister chromatid cohesion.
DNA damage induces Yap5-dependent transcription of ECO1/CTF7 in Saccharomyces cerevisiae.
Title: DNA damage induces Yap5-dependent transcription of ECO1/CTF7 in Saccharomyces cerevisiae.
The acetyltransferase Eco1 elicits cohesin dimerization during S phase.
Title: The acetyltransferase Eco1 elicits cohesin dimerization during S phase.
The authors propose that the timing of Eco1 phosphorylation, and potentially that of other DDK substrates, is determined in part by sequestration of DDK at unfired replication origins during S phase.
Title: Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction.
Eco1 mediated acetylation regulates PCNA sliding on DNA in the presence of DNA damage, favoring homologous recombination linked to sister-chromatid cohesion.
Title: Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination.
These results also suggest that Eco1 promotes cohesion by modulating the ATPase cycle of DNA-bound cohesin in a state that is permissive for DNA tethering and refractory to Wpl1 inhibition.
Title: The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering.
Eco1p-mediated acetylation promotes establishment by abrogating the ability of Wpl1p to destabilize cohesin binding to chromosomes.
Title: A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase.
Data indicate that cell cycle protein Pds5 promotes acetylation of cohesin subunit Smc3 by acetyltransferase Eco1 during S phase.
Title: Pds5 promotes and protects cohesin acetylation.
the absence of Ctf4 and Chl1, but not of the other factors, causes a synthetic growth defect in cells lacking Eco1.
Title: An Eco1-independent sister chromatid cohesion establishment pathway in S. cerevisiae.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide-lysine-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of meiotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic sister chromatid cohesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in internal peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA gene clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	HDA more info	PubMed
located_in nuclear replication fork	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Eco1p

NP_116683.1

Acetyltransferase required for sister chromatid cohesion; elicits cohesin dimerization during S phase; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by Cdc28p, Cdc7p, Mck1p to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; relative distribution to nucleus increases upon DNA replication stress; mutations in human homolog ESCO2 cause Roberts syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

207452..208297

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179992.1 → NP_116683.1 TPA: Eco1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116683.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTQ7, P43605

UniProtKB/TrEMBL

G2WDG5, N1P6T9

Conserved Domains (2) summary

pfam13878
Location:18 → 57

zf-C2H2_3; zinc-finger of acetyl-transferase ESCO

pfam13880
Location:209 → 267

Acetyltransf_13; ESCO1/2 acetyl-transferase