IRC5 putative ATPase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: IRC5
Official Full Name: putative ATPase
Primary source: SGD:S000001934
Locus tag: YFR038W
See related: AllianceGenome:SGD:S000001934; FungiDB:YFR038W; VEuPathDB:YFR038W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable several functions, including ATP hydrolysis activity; chromatin binding activity; and nucleosome array spacer activity. Involved in mitotic recombination. Acts upstream of or within error-free translesion synthesis. Located in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Irc5 is an auxiliary factor that is involved in cohesin association with chromatin in yeast.
Title: The LSH/HELLS homolog Irc5 contributes to cohesin association with chromatin in yeast.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleosome array spacer activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within error-free translesion synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_116696.2

Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and mCherry fusion proteins localize to the nucleus

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The following sections contain reference sequences that belong to a specific genome build. Explain