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ENT4 Ent4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850621, updated on 9-Dec-2024

Summary

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Official Symbol
ENT4
Official Full Name
Ent4p
Primary source
SGD:S000003961
Locus tag
YLL038C
See related
AllianceGenome:SGD:S000003961; FungiDB:YLL038C; VEuPathDB:YLL038C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable clathrin binding activity and phospholipid binding activity. Involved in protein localization to plasma membrane. Located in cytosol. Orthologous to several human genes including ENTHD1 (ENTH domain containing 1); EPN1 (epsin 1); and EPN2 (epsin 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ENT4 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (65775..66518, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene membrane morphogenesis protein VPS13 Neighboring gene ubiquitin Neighboring gene E3 ubiquitin-protein ligase PRP19 Neighboring gene polynucleotide 5'-hydroxyl-kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polarization of cell growth in yeast. Pruyne D, et al. J Cell Sci, 2000 Feb. PMID 10652251
  2. Functional analysis of six novel ORFs on the left arm of chromosome XII in Saccharomyces cerevisiae reveals two essential genes, one of which is under cell-cycle control. El-Moghazy AN, et al. Yeast, 2000 Feb. PMID 10649456
  3. Specific interaction between SNAREs and epsin N-terminal homology (ENTH) domains of epsin-related proteins in trans-Golgi network to endosome transport. Chidambaram S, et al. J Biol Chem, 2004 Feb 6. PMID 14630930
  4. Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. Wendland B, et al. EMBO J, 1999 Aug 16. PMID 10449404, Free PMC Article
  5. Long 3'-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Kebaara BW, et al. Nucleic Acids Res, 2009 May. PMID 19270062, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cortical patch assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cortical patch TAS
Traceable Author Statement
more info
 PubMed 
part_of clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ent4p
NP_013062.1
  • hypothetical protein; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    65775..66518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181858.1 → NP_013062.1  TPA: Ent4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013062.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXW8, Q07872
    UniProtKB/TrEMBL
    B3LTD5, C8ZCT6, G2WIF9, N1P1A4
    Conserved Domains (1) summary
    cd16994
    Location:15 → 132
    ENTH_Ent4; Epsin N-Terminal Homology (ENTH) domain of Yeast Ent4 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07872.1

Gene LinkOut

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