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uncharacterized protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 850670, updated on 9-Dec-2024

Summary

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Official Full Name
uncharacterized protein
Primary source
SGD:S000003979
Locus tag
YLL056C
See related
AllianceGenome:SGD:S000003979; FungiDB:YLL056C; VEuPathDB:YLL056C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aldehyde dehydrogenase (NAD+) activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (27409..28305, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cystathionine gamma-synthase Neighboring gene sulfonate dioxygenase Neighboring gene Yct1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. YLL056C from Saccharomyces cerevisiae encodes a novel protein with aldehyde reductase activity. Wang HY, et al. Appl Microbiol Biotechnol, 2017 Jun. PMID 28265724
  2. Resistance of Saccharomyces cerevisiae to high concentrations of furfural is based on NADPH-dependent reduction by at least two oxireductases. Heer D, et al. Appl Environ Microbiol, 2009 Dec. PMID 19854918, Free PMC Article
  3. The VFH1 (YLL056C) promoter is vanillin-inducible and enables mRNA translation despite pronounced translation repression caused by severe vanillin stress in Saccharomyces cerevisiae. Nguyen TTM, et al. Yeast, 2018 Jul. PMID 29575020
  4. Functional Analysis of six novel ORFs on the left arm of Chromosome XII of Saccharomyces cerevisiae reveals three of them responding to S-starvation. Zhang N, et al. Yeast, 2001 Mar 15. PMID 11223942
  5. Mechanisms of patulin toxicity under conditions that inhibit yeast growth. Iwahashi Y, et al. J Agric Food Chem, 2006 Mar 8. PMID 16506856

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of YLL056C(VFH1) is significantly induced at the protein level by severe vanillin stress in Saccharomyces cerevisiae. VFH1 promoter enables the protein synthesis of other genes including GFP and ALD6 under severe vanillin stress. Null mutant of VFH1 delays growth in the presence of vanillin, furfural and 5-hydroxymethylfural, indicating the importance of Vfh1 for sufficient tolerance against these inhibitors.
    Title: The VFH1 (YLL056C) promoter is vanillin-inducible and enables mRNA translation despite pronounced translation repression caused by severe vanillin stress in Saccharomyces cerevisiae.
  2. study reports ORF YLL056C was significantly upregulated under high furfural or 5-(hydroxymethyl)-2-furaldehyde concentrations; this ORF encoded a protein (Yll056cp), which was grouped into the atypical subgroup 7 in the short-chain dehydrogenase/reductase family and localized to the cytoplasm
    Title: YLL056C from Saccharomyces cerevisiae encodes a novel protein with aldehyde reductase activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
NP_013044.1
  • NADH-dependent aldehyde reductase; reduces many aldehyde compounds including glycolaldehyde, formaldehyde and furfural; transcription unregulated by furfural, 5-hydroxymethylfurfural (HMF) and the mycotoxin patulin; expression increased by multidrug resistance transcription factors Yrm1p and Yrr1p; member of atypical subgroup 7 of the short-chain dehydrogenase/reductase (SDR) family; localizes to the cytoplasm; SWAT-GFP and mCherry fusion proteins localize to the ER and vacuole respectively

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    27409..28305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181876.1 → NP_013044.1  TPA: uncharacterized protein YLL056C [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013044.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXV2, Q12177
    UniProtKB/TrEMBL
    A7A0K4, C7GND9, G2WIE4
    Conserved Domains (1) summary
    cd05262
    Location:1 → 291
    SDR_a7; atypical (a) SDRs, subgroup 7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12177.1

Gene LinkOut

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