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SND2 Snd2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850754, updated on 2-Nov-2024

Summary

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Official Symbol
SND2
Official Full Name
Snd2p
Primary source
SGD:S000004055
Locus tag
YLR065C
See related
AllianceGenome:SGD:S000004055; FungiDB:YLR065C; VEuPathDB:YLR065C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ENV10
Summary
Involved in vacuolar protein processing. Located in endoplasmic reticulum. Orthologous to human TMEM208 (transmembrane protein 208). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SND2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (266373..266918, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene 25S rRNA (uracil2843-N3)-methyltransferase Neighboring gene Per33p Neighboring gene signal peptidase complex subunit SPC3 Neighboring gene Pet309p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Snd3 controls nucleus-vacuole junctions in response to glucose signaling. Tosal-Castano S, et al. Cell Rep, 2021 Jan 19. PMID 33472077
  2. ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway. Xiao T, et al. Life Sci Alliance, 2021 Mar. PMID 33479049, Free PMC Article
  3. A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology. Ricarte F, et al. PLoS One, 2011. PMID 21912603, Free PMC Article
  4. Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control. Copic A, et al. Genetics, 2009 Jul. PMID 19433630, Free PMC Article
  5. Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop. Vazquez HM, et al. PLoS Genet, 2016 Jul. PMID 27462707, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Snd2p
NP_013166.1
  • Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    266373..266918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181952.1 → NP_013166.1  TPA: Snd2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013166.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY66, Q6Q5C1, Q99382
    UniProtKB/TrEMBL
    A7A0X0, B3LT35, C7GQP0, C8ZD37, G2WIQ7, N1P6E2
    Conserved Domains (1) summary
    pfam05620
    Location:1 → 171
    DUF788; Protein of unknown function (DUF788)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99382.1

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