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SPC3 signal peptidase complex subunit SPC3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850755, updated on 2-Nov-2024

Summary

Official Symbol
SPC3
Official Full Name
signal peptidase complex subunit SPC3
Primary source
SGD:S000004056
Locus tag
YLR066W
See related
AllianceGenome:SGD:S000004056; FungiDB:YLR066W; VEuPathDB:YLR066W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein targeting to ER and signal peptide processing. Located in endoplasmic reticulum. Part of signal peptidase complex. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See SPC3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (267169..267723)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Per33p Neighboring gene Snd2p Neighboring gene Pet309p Neighboring gene Fyv7p

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein targeting to ER IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal peptide processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
 
involved_in signal peptide processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of signal peptidase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of signal peptidase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
signal peptidase complex subunit SPC3
NP_013167.1
  • Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    267169..267723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181953.1NP_013167.1  TPA: signal peptidase complex subunit SPC3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013167.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY67, Q12133
    UniProtKB/TrEMBL
    A7A0X1, B3LT36, B5VMZ8, C7GQP1, C8ZD38, G2WIQ8, N1P108
    Conserved Domains (1) summary
    pfam04573
    Location:4177
    SPC22; Signal peptidase subunit