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MEF1 Mef1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850758, updated on 2-Nov-2024

Summary

Official Symbol
MEF1
Official Full Name
Mef1p
Primary source
SGD:S000004059
Locus tag
YLR069C
See related
AllianceGenome:SGD:S000004059; FungiDB:YLR069C; VEuPathDB:YLR069C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable GTPase activity and translation elongation factor activity. Involved in mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 1. Orthologous to human GFM1 (G elongation factor mitochondrial 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See MEF1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (271630..273915, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pet309p Neighboring gene Fyv7p Neighboring gene D-xylulose reductase XYL2 Neighboring gene Rgr1p

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
 
enables translation elongation factor activity ISA
Inferred from Sequence Alignment
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial translational elongation IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial translational elongation ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
Mef1p
NP_013170.1
  • Mitochondrial elongation factor involved in translational elongation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    271630..273915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181956.1NP_013170.1  TPA: Mef1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013170.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY70, P25039, Q6B1Y6, Q99360
    UniProtKB/TrEMBL
    G2WIR1, N1P6E7
    Conserved Domains (1) summary
    COG0480
    Location:68760
    FusA; Translation elongation factor EF-G, a GTPase [Translation, ribosomal structure and biogenesis]