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XYL2 D-xylulose reductase XYL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850759, updated on 2-Nov-2024

Summary

Official Symbol
XYL2
Official Full Name
D-xylulose reductase XYL2
Primary source
SGD:S000004060
Locus tag
YLR070C
See related
AllianceGenome:SGD:S000004060; FungiDB:YLR070C; VEuPathDB:YLR070C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-xylulose reductase activity. Involved in xylulose biosynthetic process. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See XYL2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (274141..275211, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fyv7p Neighboring gene Mef1p Neighboring gene Rgr1p Neighboring gene Lam6p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-xylulose reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables D-xylulose reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables L-iditol 2-dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in D-xylose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in L-arabinose catabolic process to xylulose 5-phosphate IEA
Inferred from Electronic Annotation
more info
 
involved_in sorbitol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in xylulose biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
D-xylulose reductase XYL2
NP_013171.1
  • Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    274141..275211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181957.1NP_013171.1  TPA: D-xylulose reductase XYL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013171.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY71, Q07993
    UniProtKB/TrEMBL
    A7A0X5, B3LT40, B5VN02, C7GQP5, C8ZD42, G2WIR2, N1NZI2
    Conserved Domains (1) summary
    cd05285
    Location:9354
    sorbitol_DH; Sorbitol dehydrogenase