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RGR1 Rgr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850760, updated on 14-Nov-2024

Summary

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Official Symbol
RGR1
Official Full Name
Rgr1p
Primary source
SGD:S000004061
Locus tag
YLR071C
See related
AllianceGenome:SGD:S000004061; FungiDB:YLR071C; VEuPathDB:YLR071C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MED14
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and TFIIB-class transcription factor binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. Orthologous to human MED14 (mediator complex subunit 14). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RGR1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (275378..278626, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Mef1p Neighboring gene D-xylulose reductase XYL2 Neighboring gene Lam6p Neighboring gene Rfu1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae. Sakai A, et al. Mol Cell Biol, 1990 Aug. PMID 2196447, Free PMC Article
  2. Upstream nucleosomes and Rgr1p are required for nucleosomal repression of transcription. Moss DR, et al. Mol Microbiol, 2000 Jun. PMID 10931280
  3. Postrecruitment Function of Yeast Med6 Protein during the Transcriptional Activation by Mediator Complex. Kim GS, et al. Biochem Res Int, 2018. PMID 29992056, Free PMC Article
  4. Genetic and physical interactions between yeast RGR1 and SIN4 in chromatin organization and transcriptional regulation. Jiang YW, et al. Genetics, 1995 May. PMID 7635307, Free PMC Article
  5. Architectural Mediator subunits are differentially essential for global transcription in Saccharomyces cerevisiae. Tourigny JP, et al. Genetics, 2021 Mar 31. PMID 33789343, Free PMC Article

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Architectural Mediator subunits are differentially essential for global transcription in Saccharomyces cerevisiae.
    Title: Architectural Mediator subunits are differentially essential for global transcription in Saccharomyces cerevisiae.
  2. Mediator tail subunits are required for complete repression of ADH2 expression and truncation of Med14 dramatically reduces glucose repression of ADH2/lacZ expression.
    Title: Snf1-independent, glucose-resistant transcription of Adr1-dependent genes in a mediator mutant of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables TFIIB-class transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rgr1p
NP_013172.1
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    275378..278626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181958.1 → NP_013172.1  TPA: Rgr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013172.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY72, P19263, Q07999
    UniProtKB/TrEMBL
    G2WIR3
    Conserved Domains (1) summary
    pfam08638
    Location:89 → 292
    Med14; Mediator complex subunit MED14
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19263.2

Gene LinkOut

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