LAM6 Lam6p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: LAM6
Official Full Name: Lam6p
Primary source: SGD:S000004062
Locus tag: YLR072W
See related: AllianceGenome:SGD:S000004062; FungiDB:YLR072W; VEuPathDB:YLR072W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LTC1
Summary: Enables sterol transfer activity. Involved in intracellular sterol transport. Located in mitochondria-associated endoplasmic reticulum membrane contact site; nucleus-vacuole junction; and vacuole-mitochondrion membrane contact site. Orthologous to human GRAMD1C (GRAM domain containing 1C). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables sterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables sterol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol transfer activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular sterol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sterol transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cortical endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum-plasma membrane contact site	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus-vacuole junction	IDA Inferred from Direct Assay more info	PubMed
located_in organelle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vacuole-mitochondrion membrane contact site	IDA Inferred from Direct Assay more info	PubMed

NP_013173.1

Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to ER-mitochondrial contact sites in a Tom70p- and Tom71p-dependent manner; mitochondrial localization requires GRAM domain; also localizes to ER-vacuole contact sites, in a Vac8p-dependent manner; has GRAM and StART-like (VASt) domains; one of six StART-like domain-containing proteins in yeast; conserved across eukaryotes

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The following sections contain reference sequences that belong to a specific genome build. Explain