HOG1 mitogen-activated protein kinase HOG1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HOG1
Official Full Name: mitogen-activated protein kinase HOG1
Primary source: SGD:S000004103
Locus tag: YLR113W
See related: AllianceGenome:SGD:S000004103; FungiDB:YLR113W; VEuPathDB:YLR113W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SSK3
Summary: Enables MAP kinase activity; calmodulin binding activity; and chromatin binding activity. Involved in several processes, including cellular response to osmotic stress; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to several human genes including MAPK12 (mitogen-activated protein kinase 12) and MAPK13 (mitogen-activated protein kinase 13). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See HOG1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (371620..372927)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation in Saccharomyces cerevisiae.
Title: Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation in Saccharomyces cerevisiae.
Positive feedback induces switch between distributive and processive phosphorylation of Hog1.
Title: Positive feedback induces switch between distributive and processive phosphorylation of Hog1.
Leptospiral lipopolysaccharide mediated Hog1 phosphorylation in Saccharomyces cerevisiae directs activation of autophagy.
Title: Leptospiral lipopolysaccharide mediated Hog1 phosphorylation in Saccharomyces cerevisiae directs activation of autophagy.
Cdc42-Specific GTPase-Activating Protein Rga1 Squelches Crosstalk between the High-Osmolarity Glycerol (HOG) and Mating Pheromone Response MAPK Pathways.
Title: Cdc42-Specific GTPase-Activating Protein Rga1 Squelches Crosstalk between the High-Osmolarity Glycerol (HOG) and Mating Pheromone Response MAPK Pathways.
MAP kinase Hog1 mediates a cytochrome P450 oxidoreductase to promote the Sporisorium scitamineum cell survival under oxidative stress.
Title: MAP kinase Hog1 mediates a cytochrome P450 oxidoreductase to promote the Sporisorium scitamineum cell survival under oxidative stress.
A rate threshold mechanism regulates MAPK stress signaling and survival.
Title: A rate threshold mechanism regulates MAPK stress signaling and survival.
Altered metabolic regulation owing to gsp1 mutations encoding the nuclear small G protein in Saccharomyces cerevisiae.
Title: Altered metabolic regulation owing to gsp1 mutations encoding the nuclear small G protein in Saccharomyces cerevisiae.
Thiol-based direct threat sensing by the stress-activated protein kinase Hog1.
Title: Thiol-based direct threat sensing by the stress-activated protein kinase Hog1.
In Saccharomyces cerevisiae Hog1 delays mitotic exit when cells are stressed during metaphase. Hog1 phosphorylates the nucleolar protein Net1, altering its affinity for the phosphatase Cdc14, whose activity is essential for mitotic exit and completion of the cell cycle. Saccharomyces cerevisiae strain with mutant Net1 that cannot be phosphorylated by Hog1 displays reduced viability upon osmostress.
Title: Hog1 activation delays mitotic exit via phosphorylation of Net1.
the coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network
Title: The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in cellular hyperosmotic response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular hyperosmotic response	IPI Inferred from Physical Interaction more info	PubMed
involved_in cellular response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of exit from mitosis	IDA Inferred from Direct Assay more info	PubMed
involved_in osmosensory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in osmosensory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nuclear cell cycle DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitogen-activated protein kinase HOG1

NP_013214.1

EC 2.7.11.24

Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

371620..372927

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182000.1 → NP_013214.1 TPA: mitogen-activated protein kinase HOG1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013214.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYB1, P32485, Q06232, Q12294

UniProtKB/TrEMBL

A7A115, B3LT78, B5VN49, C7GQT3, C8ZD84, G2WIV5, N1P6K6

Conserved Domains (1) summary

cd07856
Location:12 → 339

STKc_Sty1_Hog1; Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1