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CFT2 cleavage polyadenylation factor subunit CFT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850806, updated on 9-Dec-2024

Summary

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Official Symbol
CFT2
Official Full Name
cleavage polyadenylation factor subunit CFT2
Primary source
SGD:S000004105
Locus tag
YLR115W
See related
AllianceGenome:SGD:S000004105; FungiDB:YLR115W; VEuPathDB:YLR115W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YDH1
Summary
Enables RNA binding activity. Involved in mRNA processing. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CFT2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (377985..380564)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene Avl9p Neighboring gene mRNA splicing protein MSL5 Neighboring gene Clf1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A serendipitous discovery that in situ proteolysis is essential for the crystallization of yeast CPSF-100 (Ydh1p). Mandel CR, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Oct 1. PMID 17012808, Free PMC Article
  2. Cleavage factor II of Saccharomyces cerevisiae contains homologues to subunits of the mammalian Cleavage/ polyadenylation specificity factor and exhibits sequence-specific, ATP-dependent interaction with precursor RNA. Zhao J, et al. J Biol Chem, 1997 Apr 18. PMID 9099738
  3. The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development. Lardenois A, et al. Nucleic Acids Res, 2015 Jan. PMID 25477386, Free PMC Article
  4. The C terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3'-end processing. Yang F, et al. RNA, 2017 Jan. PMID 27780845, Free PMC Article
  5. A multisubunit 3' end processing factor from yeast containing poly(A) polymerase and homologues of the subunits of mammalian cleavage and polyadenylation specificity factor. Preker PJ, et al. EMBO J, 1997 Aug 1. PMID 9303317, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal structure of yeast protein CPSF-100 (Ydh1) at 2.5 A resolution
    Title: Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cleavage polyadenylation factor subunit CFT2
NP_013216.1
  • Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    377985..380564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182002.1 → NP_013216.1  TPA: cleavage polyadenylation factor subunit CFT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013216.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYB3, Q12102, Q7LGW6
    UniProtKB/TrEMBL
    A7A117, B3LT80, B5VN51, C7GQD6, N1P159
    Conserved Domains (3) summary
    smart01027
    Location:254 → 372
    Beta-Casp; Beta-Casp domain
    pfam13299
    Location:732 → 856
    CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
    pfam16661
    Location:19 → 211
    Lactamase_B_6; Metallo-beta-lactamase superfamily domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12102.1

Gene LinkOut

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