U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RNH203 Rnh203p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850847, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
RNH203
Official Full Name
Rnh203p
Primary source
SGD:S000004144
Locus tag
YLR154C
See related
AllianceGenome:SGD:S000004144; FungiDB:YLR154C; VEuPathDB:YLR154C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to RNA-DNA hybrid ribonuclease activity. Involved in RNA catabolic process. Located in cytoplasm and nucleus. Part of ribonuclease H2 complex. Used to study Aicardi-Goutieres syndrome. [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RNH203 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (447982..448314, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene acetate--CoA ligase ACS2 Neighboring gene tRNA-Gln Neighboring gene miscRNA Neighboring gene miscRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Jeong HS, et al. Nucleic Acids Res, 2004. PMID 14734815, Free PMC Article
  2. RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids. Lockhart A, et al. Cell Rep, 2019 Nov 26. PMID 31775053
  3. Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII. Rohman MS, et al. FEBS J, 2008 Oct. PMID 18721139, Free PMC Article
  4. Analysis of subunit assembly and function of the Saccharomyces cerevisiae RNase H2 complex. Nguyen TA, et al. FEBS J, 2011 Dec. PMID 22004424
  5. Defects in RNase H2 Stimulate DNA Break Repair by RNA Reverse Transcribed into cDNA. Keskin H, et al. Microrna, 2015. PMID 26456534

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA-DNA hybrid ribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA-DNA hybrid ribonuclease activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease H2 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Rnh203p
NP_013255.1
  • Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    447982..448314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182041.1 → NP_013255.1  TPA: Rnh203p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013255.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYE9, Q12338, Q6Q5B9
    UniProtKB/TrEMBL
    B3LTB5, C7GMK6, C8ZDC5, G2WIZ3, N1P191
    Conserved Domains (1) summary
    cl07291
    Location:14 → 90
    RNase_H2-C; Ribonuclease H2-C is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12338.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools