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TAG1 Tag1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850870, updated on 4-Jan-2025

Summary

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Official Symbol
TAG1
Official Full Name
Tag1p
Primary source
SGD:S000004163
Locus tag
YLR173W
See related
AllianceGenome:SGD:S000004163; FungiDB:YLR173W; VEuPathDB:YLR173W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in cellular response to nitrogen starvation and negative regulation of macroautophagy. Is active in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See TAG1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (502421..504247)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Aps1p Neighboring gene diphthine synthase Neighboring gene isocitrate dehydrogenase (NADP(+)) IDP2 Neighboring gene pseudouridine synthase CBF5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins. Levine TP. Proteins, 2022 Jan. PMID 34347309
  2. Vacuolar protein Tag1 and Atg1-Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae. Kira S, et al. J Cell Sci, 2021 Feb 26. PMID 33536246
  3. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
  4. Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability. Bryant EE, et al. Nucleic Acids Res, 2019 Sep 26. PMID 31350889, Free PMC Article
  5. The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization. Atencio D, et al. G3 (Bethesda), 2014 Mar 20. PMID 24470217, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.
    Title: TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.
  2. Vacuolar protein Tag1 and Atg1-Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae.
    Title: Vacuolar protein Tag1 and Atg1-Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to nitrogen starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of protein localization to phagophore assembly site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tag1p
NP_013274.1
  • Vacuolar membrane protein involved in termination of autophagy; regulates autophagy termination during persistent nitrogen starvation through Atg1p-mediated re-phosphorylation of Atg13p and PAS disassembly; type II membrane protein containing hydrophobic transmembrane region with N-terminal region oriented toward cytosol and C-terminus inside lumen; luminal domain is glycosylated; forms foci in vacuole membrane during starvation; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    502421..504247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182060.1 → NP_013274.1  TPA: Tag1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013274.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYH7, Q06247
    UniProtKB/TrEMBL
    A7A164, G2WJ06
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06247.1

Gene LinkOut

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