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RPL37A ribosomal 60S subunit protein L37A [ Saccharomyces cerevisiae S288C ]

Gene ID: 850882, updated on 9-Dec-2024

Summary

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Official Symbol
RPL37A
Official Full Name
ribosomal 60S subunit protein L37A
Primary source
SGD:S000004175
Locus tag
YLR185W
See related
AllianceGenome:SGD:S000004175; FungiDB:YLR185W; VEuPathDB:YLR185W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Orthologous to human RPL37 (ribosomal protein L37). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPL37A in Genome Data Viewer
Location:
chromosome: XII
Exon count:
2
Sequence:
Chromosome: XII; NC_001144.5 (522663..523288)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene transcriptional regulator SWI6 Neighboring gene Tos4p Neighboring gene 18S rRNA pseudouridine methyltransferase Neighboring gene Skg3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-Wide Dynamic Evaluation of the UV-Induced DNA Damage Response. Silva E, et al. G3 (Bethesda), 2020 Sep 2. PMID 32732306, Free PMC Article
  2. Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1. Schawalder SB, et al. Nature, 2004 Dec 23. PMID 15616569
  3. A pharmaco-epistasis strategy reveals a new cell size controlling pathway in yeast. Moretto F, et al. Mol Syst Biol, 2013 Nov 12. PMID 24217298, Free PMC Article
  4. Overexpression of budding yeast protein phosphatase Ppz1 impairs translation. Calafí C, et al. Biochim Biophys Acta Mol Cell Res, 2020 Aug. PMID 32339526
  5. Potency of CRISPR-Cas Antifungals Is Enhanced by Cotargeting DNA Repair and Growth Regulatory Machinery at the Genetic Level. Mendoza BJ, et al. ACS Infect Dis, 2023 Dec 8. PMID 37955405, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L37A
NP_013286.1
  • Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    522663..523288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182072.1 → NP_013286.1  TPA: ribosomal 60S subunit protein L37A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013286.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYI8, P49166
    UniProtKB/TrEMBL
    A7A175, B3RH76, C8ZDF6, G2WJ17
    Conserved Domains (1) summary
    PTZ00073
    Location:1 → 85
    PTZ00073; 60S ribosomal protein L37; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49166.2

Gene LinkOut

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