CLB4 B-type cyclin CLB4 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CLB4
Official Full Name: B-type cyclin CLB4
Primary source: SGD:S000004200
Locus tag: YLR210W
See related: AllianceGenome:SGD:S000004200; FungiDB:YLR210W; VEuPathDB:YLR210W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in G2/M transition of mitotic cell cycle; regulation of cell cycle process; and regulation of protein phosphorylation. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomyces cerevisiae.
Title: Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic spindle pole body separation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic spindle assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NP_013311.1

B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; CLB4 has a paralog, CLB3, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain