MAP1 methionine aminopeptidase MAP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MAP1
Official Full Name: methionine aminopeptidase MAP1
Primary source: SGD:S000004234
Locus tag: YLR244C
See related: AllianceGenome:SGD:S000004234; FungiDB:YLR244C; VEuPathDB:YLR244C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables mRNA binding activity and metalloaminopeptidase activity. Involved in negative regulation of gene expression. Located in cytosolic ribosome. Orthologous to human METAP1 (methionyl aminopeptidase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MAP1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (625168..626331, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains.
Title: The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains.
Data show that overexpression of the enzyme Map1 negatively affects the expression of experimentally defined mRNA targets.
Title: A screen for RNA-binding proteins in yeast indicates dual functions for many enzymes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables initiator methionyl aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloaminopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytosolic ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methionine aminopeptidase MAP1

NP_013345.1

EC 3.4.11.18

Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; apo-Map1p is activated by the GTP-dependent zinc transferase Zng1p, especially during zinc starvation; interacts with Zng1p via an N-terminal Zn finger domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

625168..626331 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182131.1 → NP_013345.1 TPA: methionine aminopeptidase MAP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013345.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYP2, Q01662

UniProtKB/TrEMBL

A7A1C7, B3RHC9, C7GQZ2, C8ZDK7, G2WJ70, N1NYG1

Conserved Domains (1) summary

PLN03158
Location:23 → 379

PLN03158; methionine aminopeptidase; Provisional