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GUF1 GTPase GUF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850996, updated on 4-Jan-2025

Summary

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Official Symbol
GUF1
Official Full Name
GTPase GUF1
Primary source
SGD:S000004280
Locus tag
YLR289W
See related
AllianceGenome:SGD:S000004280; FungiDB:YLR289W; VEuPathDB:YLR289W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity and mitochondrial ribosome binding activity. Involved in positive regulation of translation. Located in mitochondrial matrix. Used to study West syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 40. Orthologous to human GUF1 (GTP binding elongation factor GUF1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See GUF1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (715089..717026)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S30A Neighboring gene Mec3p Neighboring gene ubiquinone biosynthesis protein COQ11 Neighboring gene translation initiation factor eIF2B subunit beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast. Kiser GL, et al. Yeast, 1995 Oct. PMID 8553703
  2. Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Butcher RA, et al. Nat Chem Biol, 2006 Feb. PMID 16415861
  3. The membrane-bound GTPase Guf1 promotes mitochondrial protein synthesis under suboptimal conditions. Bauerschmitt H, et al. J Biol Chem, 2008 Jun 20. PMID 18442968
  4. Mrpl36 is important for generation of assembly competent proteins during mitochondrial translation. Prestele M, et al. Mol Biol Cell, 2009 May. PMID 19339279, Free PMC Article
  5. West syndrome caused by homozygous variant in the evolutionary conserved gene encoding the mitochondrial elongation factor GUF1. Alfaiz AA, et al. Eur J Hum Genet, 2016 Jul. PMID 26486472, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Guf1 promotes mitochondrial protein synthesis under suboptimal conditions
    Title: The membrane-bound GTPase Guf1 promotes mitochondrial protein synthesis under suboptimal conditions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
  
enables mitochondrial ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitochondrial ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
GTPase GUF1
NP_013392.1
  • Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    715089..717026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182177.1 → NP_013392.1  TPA: GTPase GUF1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013392.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7A1H2, B3RHG9, C8ZDQ3, D6VYT5, P46943, Q05891
    UniProtKB/TrEMBL
    B5VNJ5, C7GVU8, G2WJB3, N1NYI7
    Conserved Domains (1) summary
    COG0481
    Location:38 → 645
    LepA; Translation elongation factor EF-4, membrane-bound GTPase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46943.2

Gene LinkOut

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