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VRP1 Vrp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851051, updated on 9-Dec-2024

Summary

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Official Symbol
VRP1
Official Full Name
Vrp1p
Primary source
SGD:S000004329
Locus tag
YLR337C
See related
AllianceGenome:SGD:S000004329; FungiDB:YLR337C; VEuPathDB:YLR337C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
END5; MDP2; YLR337W
Summary
Enables actin binding activity. Involved in several processes, including actin cortical patch localization; bipolar cellular bud site selection; and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in actin cortical patch; cellular bud neck; and incipient cellular bud site. Orthologous to human WIPF1 (WAS/WASL interacting protein family member 1) and WIPF2 (WAS/WASL interacting protein family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See VRP1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (802653..805106, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene nucleoporin NUP2 Neighboring gene Sgd1p Neighboring gene ribosomal protein P0 Neighboring gene Spo77p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A proline-rich protein, verprolin, involved in cytoskeletal organization and cellular growth in the yeast Saccharomyces cerevisiae. Donnelly SF, et al. Mol Microbiol, 1993 Nov. PMID 7968536
  2. Actin binding and proline rich motifs of CR16 play redundant role in growth of vrp1Delta cells. Meng L, et al. Biochem Biophys Res Commun, 2007 May 25. PMID 17418095
  3. The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast. Vaduva G, et al. J Biol Chem, 1999 Jun 11. PMID 10358064
  4. Vrp1p-Las17p interaction is critical for actin patch polarization but is not essential for growth or fluid phase endocytosis in S. cerevisiae. Wong MH, et al. Biochim Biophys Acta, 2010 Dec. PMID 20816901
  5. Vrp1p functions in both actomyosin ring-dependent and Hof1p-dependent pathways of cytokinesis. Naqvi SN, et al. Traffic, 2001 Mar. PMID 11260524

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These studies provide evidence that WASP (Las17) and WIP (Vrp1) play central roles in establishment of a robust multivalent Src homology 3 domain-proline-rich motif network in vivo, giving Actin-related protein 2/3 complex assembly onset at endocytic sites a switch-like behavior.
    Title: Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo.
  2. Vrp1 protin is responsible for temperature sensitivity and plays a role in calcineurin activation and inhibition.
    Title: Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin.
  3. Results identify an N-terminal fragment of Las17p able to interact with Vrp1p but not Arp2/3, and suggest that LAs17 interaction with Vrp1 is more important than interaction with Arp2/3 for polarized actin assembly and endocytosis in yeast.
    Title: Las17p-Vrp1p but not Las17p-Arp2/3 interaction is important for actin patch polarization in yeast.
  4. Findings highlight the role of Las17p binding for Vrp1p membrane association, suggest general membrane association may be more important than specific targeting to the cortical actin cytoskeleton for Vrp1p. function in endocytosis and cell growth.
    Title: Verprolin function in endocytosis and actin organization. Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cortical patch localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bipolar cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip HDA PubMed 

General protein information

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Preferred Names
Vrp1p
NP_013441.1
  • Verprolin, proline-rich actin-associated protein; involved in cytoskeletal organization and cytokinesis; promotes actin nucleation and endocytosis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    802653..805106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182226.1 → NP_013441.1  TPA: Vrp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013441.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYX7, P37370, Q06133
    UniProtKB/TrEMBL
    E9PA85, N1NZN0
    Conserved Domains (2) summary
    PRK14951
    Location:109 → 240
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd22064
    Location:27 → 55
    WH2_WAS_WASL; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein (WIP)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37370.2

Gene LinkOut

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