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ARC18 Arc18p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851085, updated on 4-Jan-2025

Summary

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Official Symbol
ARC18
Official Full Name
Arc18p
Primary source
SGD:S000004362
Locus tag
YLR370C
See related
AllianceGenome:SGD:S000004362; FungiDB:YLR370C; VEuPathDB:YLR370C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable actin binding activity. Predicted to contribute to actin filament binding activity. Involved in actin cortical patch organization and establishment of mitochondrion localization. Located in mitochondrion. Part of Arp2/3 protein complex. Orthologous to human ARPC3 (actin related protein 2/3 complex subunit 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ARC18 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (861718..862254, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene SCF ubiquitin ligase complex subunit MDM30 Neighboring gene Hsp70 family ATPase SSQ1 Neighboring gene Rho family guanine nucleotide exchange factor ROM2 Neighboring gene fatty acid elongase ELO3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Actin polymerization driven mitochondrial transport in mating S. cerevisiae. Senning EN, et al. Proc Natl Acad Sci U S A, 2010 Jan 12. PMID 20080741, Free PMC Article
  2. A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast. Fehrenbacher KL, et al. Mol Biol Cell, 2005 Nov. PMID 16107558, Free PMC Article
  3. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Qureshi MS, et al. Anal Biochem, 2013 Aug 1. PMID 23583819
  4. Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Winter DC, et al. Proc Natl Acad Sci U S A, 1999 Jun 22. PMID 10377407, Free PMC Article
  5. Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast. Boldogh IR, et al. Proc Natl Acad Sci U S A, 2001 Mar 13. PMID 11248049, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARC18 protein mutant was found to be defective in apical actin patch localization.
    Title: Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cortical patch organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitochondrion localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Arp2/3 protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Arc18p
NP_013474.3
  • Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    861718..862254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182259.3 → NP_013474.3  TPA: Arc18p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013474.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ07, Q05933
    UniProtKB/TrEMBL
    A7A1P7, B3RHN7, C7GRW4, C8ZDY0, G2WJI7, N1P796
    Conserved Domains (1) summary
    pfam04062
    Location:1 → 178
    P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05933.1

Gene LinkOut

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