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CSR1 Csr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851096, updated on 4-Jan-2025

Summary

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Official Symbol
CSR1
Official Full Name
Csr1p
Primary source
SGD:S000004372
Locus tag
YLR380W
See related
AllianceGenome:SGD:S000004372; FungiDB:YLR380W; VEuPathDB:YLR380W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SFH2
Summary
Enables phosphatidylinositol transfer activity. Involved in several processes, including Golgi to plasma membrane protein transport; phosphatidylinositol metabolic process; and regulation of lipid biosynthetic process. Located in cytosol; endosome; and lipid droplet. Orthologous to human MOSPD2 (motile sperm domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CSR1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (878282..879508)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene translocon subunit SEC61 Neighboring gene uncharacterized protein Neighboring gene Ctf3p Neighboring gene leucine--tRNA ligase NAM2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily. Chen L, et al. Acta Crystallogr D Struct Biol, 2022 Jul 1. PMID 35775985
  2. SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion. Desfougères T, et al. Biochem J, 2008 Jan 1. PMID 17803462
  3. The protein interaction of Saccharomyces cerevisiae cytoplasmic thiol peroxidase II with SFH2p and its in vivo function. Cha MK, et al. J Biol Chem, 2003 Sep 12. PMID 12824182
  4. Identification of a putative DEAD-box RNA helicase and a zinc-finger protein in Candida albicans by functional complementation of the S. cerevisiae rok1 mutation. Kim WI, et al. Yeast, 2000 Mar 30. PMID 10705369
  5. Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast. Mousley CJ, et al. Biochem Soc Trans, 2006 Jun. PMID 16709158

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
    Title: Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
  2. Sfh2p inhibits fatty acid synthase activity in response to haem depletion
    Title: SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion.
  3. This review describes how overexpression of Sec14p-like protein SFH2 (Sec Fourteen Homologue 2) rescues sec14-1(temperature-sensitive)-associated growth and secretory defects.
    Title: Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylinositol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi to plasma membrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of phosphatidylglycerol biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of phosphatidylcholine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in prospore membrane HDA PubMed 

General protein information

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Preferred Names
Csr1p
NP_013484.3
  • Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    878282..879508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182269.3 → NP_013484.3  TPA: Csr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013484.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ15, Q06705, Q6B265
    UniProtKB/TrEMBL
    A7A1Q5, B3RHP5, B5VNR6, C7GXI4, C8ZDZ0, G2WJJ5, N1NZS0
    Conserved Domains (2) summary
    pfam00650
    Location:168 → 312
    CRAL_TRIO; CRAL/TRIO domain
    pfam03765
    Location:82 → 130
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06705.1

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