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DUS4 tRNA dihydrouridine synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851121, updated on 4-Jan-2025

Summary

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Official Symbol
DUS4
Official Full Name
tRNA dihydrouridine synthase
Primary source
SGD:S000004397
Locus tag
YLR405W
See related
AllianceGenome:SGD:S000004397; FungiDB:YLR405W; VEuPathDB:YLR405W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tRNA dihydrouridine synthase activity. Involved in tRNA modification. Orthologous to human DUS4L (dihydrouridine synthase 4 like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See DUS4 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (929789..930892)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene zinc-coordinating transcription factor SFP1 Neighboring gene seipin Neighboring gene ribosomal 60S subunit protein L31B Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. Xing F, et al. J Biol Chem, 2004 Apr 23. PMID 14970222
  2. Rapid tRNA decay can result from lack of nonessential modifications. Alexandrov A, et al. Mol Cell, 2006 Jan 6. PMID 16387656
  3. Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1). Millson S, et al. Cell Stress Chaperones, 2014 Sep. PMID 24452458, Free PMC Article
  4. Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Reid RJ, et al. Genome Res, 2011 Mar. PMID 21173034, Free PMC Article
  5. Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions. León Ortiz AM, et al. DNA Repair (Amst), 2011 May 5. PMID 21459050, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA-dihydrouridine20a synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-dihydrouridine20b synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA dihydrouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
tRNA dihydrouridine synthase
NP_013509.1
  • Dihydrouridine synthase; modifies pre-tRNAs at U20a and U20b of the D loop; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    929789..930892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182293.1 → NP_013509.1  TPA: tRNA dihydrouridine synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013509.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ38, Q06063
    UniProtKB/TrEMBL
    B3RHR7, C8ZE14, N1P7C8
    Conserved Domains (1) summary
    pfam01207
    Location:45 → 361
    Dus; Dihydrouridine synthase (Dus)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06063.1

Gene LinkOut

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