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IMD3 IMP dehydrogenase IMD3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851152, updated on 9-Dec-2024

Summary

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Official Symbol
IMD3
Official Full Name
IMP dehydrogenase IMD3
Primary source
SGD:S000004424
Locus tag
YLR432W
See related
AllianceGenome:SGD:S000004424; FungiDB:YLR432W; VEuPathDB:YLR432W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Predicted to be involved in GTP biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to several human genes including IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See IMD3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1002557..1004128)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene DNA/RNA helicase SEN1 Neighboring gene Atg23p Neighboring gene calcineurin catalytic subunit A Neighboring gene Tsr2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dissection of the molecular basis of mycophenolate resistance in Saccharomyces cerevisiae. Jenks MH, et al. Yeast, 2005 Nov. PMID 16278936
  2. Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. Köhler GA, et al. J Bacteriol, 1997 Apr. PMID 9079920, Free PMC Article
  3. Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. Hyle JW, et al. J Biol Chem, 2003 Aug 1. PMID 12746440, Free PMC Article
  4. Participation of yeast inosine 5'-monophosphate dehydrogenase in an in vitro complex with a fragment of the C-rich telomeric strand. Cornuel JF, et al. Biochimie, 2002 Apr. PMID 12106905
  5. IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II. Park JH, et al. Biochem Biophys Res Commun, 2010 Feb 19. PMID 20097157

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables IMP dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IMP dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables IMP dehydrogenase activity TAS
Traceable Author Statement
more info
 PubMed 
enables mRNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GTP biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
IMP dehydrogenase IMD3
NP_013536.3
  • Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1002557..1004128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182320.3 → NP_013536.3  TPA: IMP dehydrogenase IMD3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013536.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ67, P50095
    UniProtKB/TrEMBL
    A7A1V2, B3RHU1, C7GSM3, C8ZE40, G2WJP3, N1P1X9
    Conserved Domains (1) summary
    PTZ00314
    Location:21 → 518
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50095.1

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