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CLN3 cyclin CLN3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851191, updated on 9-Dec-2024

Summary

Official Symbol
CLN3
Official Full Name
cyclin CLN3
Primary source
SGD:S000000038
Locus tag
YAL040C
See related
AllianceGenome:SGD:S000000038; FungiDB:YAL040C; VEuPathDB:YAL040C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DAF1; FUN10; WHI1
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including G1/S transition of mitotic cell cycle; traversing start control point of mitotic cell cycle; and vacuole fusion, non-autophagic. Located in nucleus. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); endocrine gland cancer (multiple); hematologic cancer (multiple); and hepatitis B. Orthologous to several human genes including CCNA1 (cyclin A1); CCNA2 (cyclin A2); and CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See CLN3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (65778..67520, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Erv46p Neighboring gene Rho family guanine nucleotide exchange factor CDC24 Neighboring gene holocytochrome c synthase CYC3 Neighboring gene pyruvate kinase CDC19

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
cyclin CLN3
NP_009360.1
  • G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetyl-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    65778..67520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178185.1NP_009360.1  TPA: cyclin CLN3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009360.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPH6, E9P940, P13365
    UniProtKB/TrEMBL
    B3LUX6, B5VDH7, C7GPJ7, C8Z3E9, N1P920
    Conserved Domains (1) summary
    COG5024
    Location:35576
    COG5024; Cyclin [Cell division and chromosome partitioning]