CYC3 holocytochrome c synthase CYC3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CYC3
Official Full Name: holocytochrome c synthase CYC3
Primary source: SGD:S000000037
Locus tag: YAL039C
See related: AllianceGenome:SGD:S000000037; FungiDB:YAL039C; VEuPathDB:YAL039C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables holocytochrome-c synthase activity. Involved in cytochrome c-heme linkage. Located in mitochondrial intermembrane space. Used to study microphthalmia. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables holocytochrome-c synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables holocytochrome-c synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables holocytochrome-c synthase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytochrome c-heme linkage	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_009361.1

Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in mitochondrial intermembrane space; human homolog HCCS implicated in microphthalmia with linear skin defects (MLS), and can complement yeast null mutant

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