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FRT2 Frt2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851205, updated on 4-Jan-2025

Summary

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Official Symbol
FRT2
Official Full Name
Frt2p
Primary source
SGD:S000000026
Locus tag
YAL028W
See related
AllianceGenome:SGD:S000000026; FungiDB:YAL028W; VEuPathDB:YAL028W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HPH2
Summary
Involved in cellular response to alkaline pH and cellular response to salt stress. Acts upstream of or within post-translational protein targeting to membrane, translocation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See FRT2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (92900..94486)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene SNAP receptor SNC1 Neighboring gene myosin 4 Neighboring gene DNA-binding protein SAW1 Neighboring gene aminophospholipid-translocating P4-type ATPase DRS2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae. Heath VL, et al. Eukaryot Cell, 2004 Jun. PMID 15189990, Free PMC Article
  2. Genetic architecture of Hsp90-dependent drug resistance. Cowen LE, et al. Eukaryot Cell, 2006 Dec. PMID 17056742, Free PMC Article
  3. Yeast adapts to a changing stressful environment by evolving cross-protection and anticipatory gene regulation. Dhar R, et al. Mol Biol Evol, 2013 Mar. PMID 23125229
  4. Metabolic control of antifungal drug resistance. Robbins N, et al. Fungal Genet Biol, 2010 Feb. PMID 19595784
  5. Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis. Piña FJ, et al. Eukaryot Cell, 2011 Jan. PMID 21097665, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis
    Title: Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis.
  2. Hph2p neither interacts with nor is dephosphorylated by calcineurin.
    Title: Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to alkaline pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-translational protein targeting to membrane, translocation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Frt2p
NP_009374.1
  • Tail-anchored ER membrane hypothetical protein; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    92900..94486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178173.1 → NP_009374.1  TPA: Frt2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009374.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPJ0, P39733, P39734
    UniProtKB/TrEMBL
    B3LUW2, C7GPK7, N1PAY9
    Conserved Domains (1) summary
    pfam13694
    Location:86 → 280
    Hph; Sec63/Sec62 complex-interacting family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39734.2

Gene LinkOut

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