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ATS1 Ats1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851213, updated on 9-Dec-2024

Summary

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Official Symbol
ATS1
Official Full Name
Ats1p
Primary source
SGD:S000000018
Locus tag
YAL020C
See related
AllianceGenome:SGD:S000000018; FungiDB:YAL020C; VEuPathDB:YAL020C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DPH8; FUN28; KTI13
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in tRNA wobble uridine modification. Acts upstream of or within protein histidyl modification to diphthamide. Located in cytoplasm. Orthologous to human SERGEF (secretion regulating guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ATS1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (113614..114615, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene nucleoside transmembrane transporter FUN26 Neighboring gene CCR4-NOT core exoribonuclease subunit CCR4 Neighboring gene DNA-dependent ATPase FUN30 Neighboring gene Lds1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2. Arend M, et al. Microb Cell, 2023 Sep 4. PMID 37662670, Free PMC Article
  2. Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification. Kolaj-Robin O, et al. FEBS J, 2015 Mar. PMID 25604895
  3. Gene set coregulated by the Saccharomyces cerevisiae nonsense-mediated mRNA decay pathway. Taylor R, et al. Eukaryot Cell, 2005 Dec. PMID 16339724, Free PMC Article
  4. Overexpression of yeast homologs of the mammalian checkpoint gene RCC1 suppresses the class of alpha-tubulin mutations that arrest with excess microtubules. Kirkpatrick D, et al. Genetics, 1994 Jun. PMID 8070652, Free PMC Article
  5. KTI11 and KTI13, Saccharomyces cerevisiae genes controlling sensitivity to G1 arrest induced by Kluyveromyces lactis zymocin. Fichtner L, et al. Mol Microbiol, 2002 May. PMID 11994165

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Insight into the molecular mechanisms that allow the Kti11/Kti13 heterodimer to coregulate two consecutive steps in ribosomal protein synthesis.
    Title: Structure of the Kti11/Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic elongation factor 2.
  2. Kti11 forms a stable 1 : 1 complex with Kti13.In the complex, Kti13 orients Kti11 and restricts access to its electron-carrying iron atom, constraining the electron transfer capacity of Kti11.
    Title: Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification.
  3. Kti13 and Kti11 support Elongator functions and they both share Elongator-independent roles that are important for cell viability.
    Title: Yeast alpha-tubulin suppressor Ats1/Kti13 relates to the Elongator complex and interacts with Elongator partner protein Kti11.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein histidyl modification to diphthamide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ats1p
NP_009382.2
  • Protein required for modification of wobble nucleosides in tRNA; acts with Elongator complex, Kti11p, and Kti12p; has a potential role in regulatory interactions between microtubules and the cell cycle; forms a stable heterodimer with Kti11p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    113614..114615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178165.2 → NP_009382.2  TPA: Ats1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009382.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPJ8, P31386
    UniProtKB/TrEMBL
    A7A0E8, B3LUV4, C7GPL5, C8Z3K7, G2W8L2, N1P7K0
    Conserved Domains (1) summary
    COG5184
    Location:1 → 333
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31386.2

Gene LinkOut

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