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SPC72 gamma-tubulin complex subunit SPC72 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851250, updated on 4-Jan-2025

Summary

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Official Symbol
SPC72
Official Full Name
gamma-tubulin complex subunit SPC72
Primary source
SGD:S000000045
Locus tag
YAL047C
See related
AllianceGenome:SGD:S000000045; FungiDB:YAL047C; VEuPathDB:YAL047C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LDB4
Summary
Enables microtubule lateral binding activity and microtubule plus-end binding activity. Involved in gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body; microtubule cytoskeleton organization; and mitotic spindle orientation checkpoint signaling. Located in mitotic spindle astral microtubule end and outer plaque of mitotic spindle pole body. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SPC72 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (54989..56857, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene protein AIM2 Neighboring gene ERMES complex Ca(2+)-binding regulatory GTPase GEM1 Neighboring gene Bol3p Neighboring gene Bol1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SPC72: a spindle pole component required for spindle orientation in the yeast Saccharomyces cerevisiae. Souès S, et al. J Cell Sci, 1998 Sep. PMID 9718373
  2. Stu2p: A microtubule-binding protein that is an essential component of the yeast spindle pole body. Wang PJ, et al. J Cell Biol, 1997 Dec 1. PMID 9382872, Free PMC Article
  3. Mitotic exit network controls the localization of Cdc14 to the spindle pole body in Saccharomyces cerevisiae. Yoshida S, et al. Curr Biol, 2002 Jun 4. PMID 12062061
  4. Nud1p, the yeast homolog of Centriolin, regulates spindle pole body inheritance in meiosis. Gordon O, et al. EMBO J, 2006 Aug 23. PMID 16888627, Free PMC Article
  5. Spatial cues and not spindle pole maturation drive the asymmetry of astral microtubules between new and preexisting spindle poles. Lengefeld J, et al. Mol Biol Cell, 2018 Jan 1. PMID 29142076, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast.
    Title: The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast.
  2. Functions of Nud1p are connected to the ability of Spc72p to bind to the outer plaque and half-bridge (via Kar1p) of the SPB.
    Title: Nud1p, the yeast homolog of Centriolin, regulates spindle pole body inheritance in meiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables microtubule lateral binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in astral microtubule anchoring at mitotic spindle pole body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in karyogamy IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle orientation checkpoint signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic spindle orientation checkpoint signaling IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle astral microtubule end IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer plaque of mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer plaque of spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole body IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-tubulin complex subunit SPC72
NP_009352.2
  • Gamma-tubulin small complex (gamma-TuSC) receptor; recruits the gamma-TuSC complex to the cytoplasmic side of the SPB, connecting nuclear microtubules to the SPB; involved in astral microtubule formation, stabilization, and with Stu2p, anchoring astral MTs at the cytoplasmic face of the SPB, and regulating plus-end MT dynamics; regulated by Cdc5 kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    54989..56857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178192.2 → NP_009352.2  TPA: gamma-tubulin complex subunit SPC72 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009352.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPG9, E9P941, P39723
    UniProtKB/TrEMBL
    G2W8I3
    Conserved Domains (2) summary
    TIGR02169
    Location:295 → 578
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam12808
    Location:573 → 614
    Mto2_bdg; Micro-tubular organizer Mto1 C-term Mto2-binding region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39723.2

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