U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GGC1 Ggc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851329, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
GGC1
Official Full Name
Ggc1p
Primary source
SGD:S000002357
Locus tag
YDL198C
See related
AllianceGenome:SGD:S000002357; FungiDB:YDL198C; VEuPathDB:YDL198C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SHM1; YHM1
Summary
Enables guanine nucleotide transmembrane transporter activity. Involved in several processes, including guanine nucleotide transport; intracellular iron ion homeostasis; and mitochondrial genome maintenance. Located in mitochondrion. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GGC1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (103649..104551, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene methylated-DNA--protein-cysteine methyltransferase Neighboring gene uncharacterized protein Neighboring gene Asf2p Neighboring gene Sec31p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Role of YHM1, encoding a mitochondrial carrier protein, in iron distribution of yeast. Lesuisse E, et al. Biochem J, 2004 Mar 1. PMID 14629196, Free PMC Article
  2. Mapping conformational heterogeneity of mitochondrial nucleotide transporter in uninhibited states. Sounier R, et al. Angew Chem Int Ed Engl, 2015 Feb 16. PMID 25605594, Free PMC Article
  3. Identification of the mitochondrial GTP/GDP transporter in Saccharomyces cerevisiae. Vozza A, et al. J Biol Chem, 2004 May 14. PMID 14998997
  4. SHM1: a multicopy suppressor of a temperature-sensitive null mutation in the HMG1-like abf2 gene. Kao LR, et al. Yeast, 1996 Sep 30. PMID 8905928
  5. Co-precipitation of phosphate and iron limits mitochondrial phosphate availability in Saccharomyces cerevisiae lacking the yeast frataxin homologue (YFH1). Seguin A, et al. J Biol Chem, 2011 Feb 25. PMID 21189251, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GGC1, a mitochondrial GTP/GDP carrier, was identified as a new component of the rapamycin/target of rapamycin (TOR) signaling pathway.
    Title: Delayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanine nucleotide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanine nucleotide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in guanine nucleotide transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in guanine nucleotide transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Ggc1p
NP_010083.1
  • Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    103649..104551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180258.1 → NP_010083.1  TPA: Ggc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010083.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRF6, P38988
    UniProtKB/TrEMBL
    A6ZXD5, B3LH79, C7GV59, C8Z6A6, G2WBW9, N1P8H5
    Conserved Domains (1) summary
    pfam00153
    Location:206 → 286
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38988.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools