SNF3 glucose sensor [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SNF3
Official Full Name: glucose sensor
Primary source: SGD:S000002353
Locus tag: YDL194W
See related: AllianceGenome:SGD:S000002353; FungiDB:YDL194W; VEuPathDB:YDL194W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable carbohydrate:proton symporter activity. Involved in glucose mediated signaling pathway; hexose transmembrane transport; and negative regulation of meiotic nuclear division. Located in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SNF3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (111580..114234)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.
Title: Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.
Rgt2 and Snf3 glucose sensors are primary targets of methylglyoxal, which causes degradation of the Rgt2 and Snf3.
Title: The glucose metabolite methylglyoxal inhibits expression of the glucose transporter genes by inactivating the cell surface glucose sensors Rgt2 and Snf3 in yeast.
Mth1 and Std1, which are downstream effectors of the Snf3/Rgt2 pathway, were required for viability through mitochondrial function but not fermentative metabolism
Title: Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast.
Snf3 apparent affinity for glucose was lowest when the intracellular glucose concentration was high. The results conform to an alternating-access model for transporter-like sensors
Title: Conditions with high intracellular glucose inhibit sensing through glucose sensor Snf3 in Saccharomyces cerevisiae.
This study reveals that Snf3, in addition to glucose, also senses fructose and mannose, as well as the glucose analogues 2-deoxyglucose, 3-O-methylglucoside and 6-deoxyglucose.
Title: Amino acid residues involved in ligand preference of the Snf3 transporter-like sensor in Saccharomyces cerevisiae.
Suppression of the snf3 mutant phenotype by deletion of IRA2 was confirmed.
Title: Loss of IRA2 suppresses the growth defect on low glucose caused by the snf3 mutation in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables D-glucose binding	TAS Traceable Author Statement more info	PubMed
enables carbohydrate:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mannose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucose sensor

NP_010087.1

Plasma membrane low glucose sensor, regulates glucose transport; high affinity sensor that contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

111580..114234

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180254.1 → NP_010087.1 TPA: glucose sensor [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010087.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRF9, P10870

UniProtKB/TrEMBL

A6ZXD8, B5VF82, N1PAH0

Conserved Domains (1) summary

cd17356
Location:99 → 556

MFS_HXT; Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins